College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou310014, P. R. China.
J Org Chem. 2020 Jun 19;85(12):7674-7682. doi: 10.1021/acs.joc.0c00113. Epub 2020 Jun 4.
A facile Fe(III)-catalyzed oxidative decarboxylative radical coupling reaction of α,α-difluoroarylacetic acids with coumarins has been developed. This transformation, which provides a series of C-3 difluoroarylmethylated coumarins containing various functional groups in moderate-to-good yields, features easily accessible starting materials and operational simplicity.
一种简便的 Fe(III)-催化的 α,α-二氟芳基乙酸与香豆素的氧化脱羧基自由基偶联反应已经被开发出来。这种转化提供了一系列含有各种官能团的 C-3 二氟芳甲基取代香豆素，产率中等至良好，具有易于获得的起始原料和操作简单的特点。
