First Affiliated Hospital, Shantou University Medical College, Shantou 515041, China.
Department of Forensic Medicine, Shantou University Medical College, Shantou 515041, China.
Biomark Med. 2020 Feb;14(2):119-130. doi: 10.2217/bmm-2019-0176. Epub 2020 Feb 14.
We aimed to identify metabolic characteristics of early-stage heart failure (HF) and related biomarkers. One hundred and forty-three patients with New York Heart Association class I-IV HF and 34 healthy controls were recruited. Serum metabolic characteristics of class I HF were analyzed and compared with those of class II-IV HF. Potential biomarkers of class I HF with normal N-terminal-pro-B-type natriuretic peptide (NT-proBNP) level were screened and validated in additional 72 subjects (46 class I patients and 26 controls). Eleven metabolites were found disturbed in class I HF, and five of which were also disturbed in class II-IV HF. Glutamine and tyrosine showed high value to identify class I HF with normal NT-proBNP level. The diagnostic potential of glutamine was partially confirmed in the validate set, holding a promise to detect early HF with normal NT-proBNP level.
我们旨在确定早期心力衰竭（HF）的代谢特征和相关生物标志物。招募了 143 名纽约心脏协会（NYHA）I-IV 级 HF 患者和 34 名健康对照者。分析了 I 级 HF 的血清代谢特征，并与 II-IV 级 HF 进行了比较。在另外 72 名受试者（46 名 I 级患者和 26 名对照者）中筛选和验证了具有正常 N 端前 B 型利钠肽（NT-proBNP）水平的 I 级 HF 的潜在生物标志物。在 I 级 HF 中发现 11 种代谢物紊乱，其中 5 种在 II-IV 级 HF 中也存在紊乱。谷氨酰胺和酪氨酸在鉴别具有正常 NT-proBNP 水平的 I 级 HF 方面具有较高的价值。谷氨酰胺的诊断潜力在验证组中得到了部分证实，有望检测具有正常 NT-proBNP 水平的早期 HF。
