Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Fetal Pediatr Pathol. 2021 Dec;40(6):638-652. doi: 10.1080/15513815.2020.1723149. Epub 2020 Feb 14.
This meta-analysis evaluates the correlation between the IL-6 -174 G > C polymorphism and susceptibility of childhood sepsis. We searched PubMed, ISI Web of Knowledge, Scopus, CNKI, SID, SciELO databases until December 30, 2019 to identify all eligible studies. A total of 17 studies with 1,287 cases and 2,482 controls were identified. Pooled data revealed that there was no significant association between the IL-6 -174 G > C polymorphism and risk childhood sepsis in the overall population. When stratified analysis was carried out by age group of cases, no associations were found in neonates and pediatrics. However, in ethnicity-based subgroups, a significant association was found in Caucasians and Africans. There was no significant association of the IL-6 -174G > C polymorphism with susceptibility to sepsis in childhood overall, but there was an association with the Caucasian and African ethnic subgroups.
这项荟萃分析评估了 IL-6-174G>C 多态性与儿童败血症易感性之间的相关性。我们检索了 PubMed、ISI Web of Knowledge、Scopus、CNKI、SID、SciELO 数据库，截至 2019 年 12 月 30 日，以确定所有符合条件的研究。共纳入 17 项研究，包括 1287 例病例和 2482 例对照。汇总数据显示，IL-6-174G>C 多态性与儿童败血症的总体风险之间无显著相关性。按病例年龄组进行分层分析时，在新生儿和儿科中未发现相关性。然而，在基于种族的亚组中，白种人和非洲人存在显著相关性。IL-6-174G>C 多态性与儿童败血症的易感性总体上无显著相关性，但与白种人和非洲种族亚组有关。
