Department of Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom; UK Dementia Research Institute at University College, London, United Kingdom.
Department of Neuromuscular Diseases, UCL Institute of Neurology, London, United Kingdom.
Prog Brain Res. 2020;251:181-208. doi: 10.1016/bs.pbr.2019.10.004. Epub 2019 Nov 29.
People who have Down syndrome are at significantly elevated risk of developing early onset Alzheimer's disease that causes dementia (AD-DS). Here we review recent progress in modeling the development of AD-DS in mouse models. These studies provide insight into mechanisms underlying Alzheimer's disease and generate new clinical research questions. In addition, they suggest potential new targets for disease prevention therapies.
唐氏综合征患者发生早发性阿尔茨海默病痴呆（AD-DS）的风险显著增加。在此，我们综述了近年来在小鼠模型中模拟 AD-DS 发展的研究进展。这些研究为阿尔茨海默病的发病机制提供了新的认识，并提出了新的临床研究问题。此外，它们还提示了疾病预防治疗的潜在新靶点。
