Montandon Marie-Louise, Herrmann François R, Garibotto Valentina, Rodriguez Cristelle, Haller Sven, Giannakopoulos Panteleimon
Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thônex, Switzerland; Department of Psychiatry, University of Geneva, Thônex, Switzerland.
Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Thônex, Switzerland.
Neurobiol Aging. 2020 Mar;87:108-114. doi: 10.1016/j.neurobiolaging.2019.12.002. Epub 2019 Dec 11.
Mesial temporal lobe (MTL) is prominently affected in normal aging and associated with neurodegeneration in AD. Whether or not MTL atrophy is dependent on increasing amyloid load before the emergence of cognitive deficits is still disputed. We performed a 4.5-year longitudinal study in 75 older community dwellers (48 women, mean age: 79.3 years) including magnetic resonance imaging at baseline and follow-up, positron emission tomography amyloid during follow-up, neuropsychological assessment at 18 and 55 months, and APOE genotyping. Linear regression models were used to identify predictors of the MTL volume loss. Amyloid load was negatively associated with bilateral MTL volume at baseline explaining almost 10.5% of its variability. In multivariate models including time of follow-up and demographic variables (older age, male gender), this percentage exceeded 35%. The APOE4 allele independently contributed another 6%. Cognitive changes had a modest but still significant negative association with MTL volume loss. Our data support a multifactorial model including amyloid deposition, older age, male gender, APOE4 allele, and slight decline of cognitive abilities as independent predictors of MTL volume loss in brain aging.
内侧颞叶（MTL）在正常衰老过程中受到显著影响，且与阿尔茨海默病（AD）中的神经退行性变相关。在认知缺陷出现之前，MTL萎缩是否依赖于淀粉样蛋白负荷的增加仍存在争议。我们对75名社区老年居民（48名女性，平均年龄：79.3岁）进行了一项为期4.5年的纵向研究，包括在基线和随访时进行磁共振成像、随访期间进行正电子发射断层扫描淀粉样蛋白检测、在18个月和55个月时进行神经心理学评估以及APOE基因分型。使用线性回归模型来确定MTL体积损失的预测因素。淀粉样蛋白负荷与基线时双侧MTL体积呈负相关，解释了其近10.5%的变异性。在包括随访时间和人口统计学变量（年龄较大、男性）的多变量模型中，这一百分比超过了35%。APOE4等位基因独立贡献了另外6%。认知变化与MTL体积损失呈适度但仍显著的负相关。我们的数据支持一种多因素模型，该模型包括淀粉样蛋白沉积、年龄较大、男性、APOE4等位基因以及认知能力的轻微下降，这些都是脑老化中MTL体积损失的独立预测因素。
