Department of Radiology, The First Affiliated Hospital of University of South China, Chuanshan Road No. 69, Hengyang 421000, Hunan, China.
Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Acad Radiol. 2020 Dec;27(12):1774-1783. doi: 10.1016/j.acra.2020.01.006. Epub 2020 Feb 10.
Texture analysis is an emerging field that allows mathematical detection of changes in MRI signals that are not visible among image pixels. Alzheimer's disease, a progressive neurodegenerative disease, is the most common cause of dementia. Recently, multiple texture analysis studies in patients with Alzheimer's disease have been performed. This review summarizes the main contributors to Alzheimer's disease-associated cognitive decline, presents a brief overview of texture analysis, followed by review of various MR imaging texture analysis applications in Alzheimer's disease. We also discuss the current challenges for widespread clinical utilization. MR texture analysis could potentially be applied to develop neuroimaging biomarkers for use in Alzheimer's disease clinical trials and diagnosis.
纹理分析是一个新兴领域，它可以通过数学方法检测到 MRI 信号中的变化，而这些变化在图像像素中是不可见的。阿尔茨海默病是一种进行性神经退行性疾病，是痴呆最常见的病因。最近，已经有多项针对阿尔茨海默病患者的纹理分析研究。本综述总结了与阿尔茨海默病相关认知能力下降相关的主要因素，简要概述了纹理分析，接着回顾了阿尔茨海默病中各种磁共振成像纹理分析的应用。我们还讨论了目前广泛应用于临床所面临的挑战。磁共振纹理分析可能有助于开发神经影像学生物标志物，用于阿尔茨海默病临床试验和诊断。
