Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Diabetes Res Clin Pract. 2020 Apr;162:108083. doi: 10.1016/j.diabres.2020.108083. Epub 2020 Feb 11.
The aim of this paper is to observe the change of aqueous humor levels of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR) patients before and one week after intravitreal conbercept injection.
A prospective case series study was conducted in 24 active PDR patients (24 eyes). All the patients had received 0.5 mg of intravitreal conbercept followed by vitrectomy one week later. The aqueous humor was collected before conbercept injection and at the beginning of vitrectomy.
Before conbercept injection, the aqueous humor median levels of VEGF-A, VEGF-B and PlGF were457.0pg/mL(IQRfrom392.9to860.6pg/mL), 43.6pg/mL(IQRfrom33.6to81.6pg/mL), 37.5pg/mL(IQRfrom25.0to53.6pg/mL), respectively. One week after conbercept injection, the aqueous humor levels of VEGF-A, VEGF-B and PiGF decreased significantly. The aqueous humor VEGF-A levels in PDR patients with fibrovascular membranes were lower than those without them. There was positive correlation between aqueous humor VEGF-B and PiGF levels (P = 0.007). No significant correlation was found between VEGF-A and PiGF levels. No ocular and systemic adverse events were observed.
The aqueous humor levels of PlGF was correlated with VEGF-B, and levels of VEGF-A, VEGF-B, and PlGF decreased after intravitreal conbercept injection in active PDR patients.
本文旨在观察增生型糖尿病视网膜病变（PDR）患者玻璃体腔内注射康柏西普前后房水中胎盘生长因子（PlGF）和血管内皮生长因子（VEGF）水平的变化。
前瞻性病例系列研究纳入 24 例活跃性 PDR 患者（24 只眼）。所有患者均接受 0.5mg 玻璃体腔内康柏西普注射，1 周后行玻璃体切除术。于康柏西普注射前和玻璃体切除术前采集房水。
康柏西普注射前，房水中 VEGF-A、VEGF-B 和 PlGF 的中位数水平分别为 457.0pg/mL（IQR 为 392.9pg/mL 至 860.6pg/mL）、43.6pg/mL（IQR 为 33.6pg/mL 至 81.6pg/mL）和 37.5pg/mL（IQR 为 25.0pg/mL 至 53.6pg/mL）。玻璃体腔内注射康柏西普 1 周后，VEGF-A、VEGF-B 和 PlGF 水平均显著下降。伴有纤维血管膜的 PDR 患者房水中 VEGF-A 水平低于无纤维血管膜者。房水中 VEGF-B 与 PlGF 水平呈正相关（P=0.007）。VEGF-A 与 PlGF 水平无显著相关性。未观察到眼部和全身不良事件。
在活跃性 PDR 患者中，房水中 PlGF 与 VEGF-B 相关，玻璃体腔内注射康柏西普后 VEGF-A、VEGF-B 和 PlGF 水平下降。
