School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99163, USA; National Chung-Shan Institute of Science & Technology, Materials and Electro-Optics Research Division, Composite Materials Section, Taoyuan City, 32546, Taiwan, ROC.
Department of Chemical & Materials Engineering, University of Idaho, Moscow, ID, 83843 USA.
Colloids Surf B Biointerfaces. 2020 May;189:110799. doi: 10.1016/j.colsurfb.2020.110799. Epub 2020 Jan 28.
Titanium (Ti) and its alloys (especially Ti-6Al-4V or Ti64) are commonly used as load-bearing implants because of their biocompatibility and resistance to fatigue and corrosion. However, Ti/alloys are bio-inert metals and not prone to osseointegration. In order to further improve the bioactivity and osseointegration of Ti64, this study evaluated the modification of the Ti64 surface with a deposited chlorine substituted hydroxyapatite (ClHAP)/polydopamine (Pda) composite coating. Pda serves as an adhesion molecule and ClHAP releases slight acidity that stimulates osteoclastic activity. The composite coating with 10-30 % ClHAP particles is shown to promote bioactivity as evidenced by osteoblast proliferation. Therefore, this coating approach may enhance osseointegration in vivo.
钛（Ti）及其合金（尤其是 Ti-6Al-4V 或 Ti64）因其生物相容性、抗疲劳和抗腐蚀性能而被广泛用作承重植入物。然而，Ti/合金是生物惰性金属，不易骨整合。为了进一步提高 Ti64 的生物活性和骨整合性，本研究评估了用沉积的氯取代羟磷灰石（ClHAP）/聚多巴胺（Pda）复合涂层来修饰 Ti64 表面。Pda 作为一种黏附分子，ClHAP 释放出轻微的酸性，刺激破骨细胞活性。含有 10-30% ClHAP 颗粒的复合涂层显示出促进成骨细胞增殖的生物活性。因此，这种涂层方法可能会增强体内的骨整合。
