Beijing National Laboratory for Molecular Sciences , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , China.
Knee Surgery Department of the Institute of Sports Medicine , Peking University Third Hospital , Beijing 100191 , China.
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):9132-9140. doi: 10.1021/acsami.0c01022. Epub 2020 Feb 14.
Designing versatile functional medical adhesives with injectability, self-healing, and strong adhesion is of great significance to achieve desirable therapeutic effects for promoting wound sealing in healthcare. Herein, a self-healing injectable adhesive is fabricated by physical interaction of polyphenol compound tannic acid (TA) and eight-arm poly(ethylene glycol) end-capped with succinimide glutarate active ester (PEG-SG). The hydrogen bonding induced from the structural unit (-CH-CH-O-) of PEG and catechol hydroxyl (-OH) of TA, accompanied by ester exchange between -hydroxysuccinimide (-NHS) and amino (-NH) of proteins, contributes to self-healing ability and rapid strong adhesion. Notably, the PEG/TA adhesive can repeatedly adhere to rigid porcine tissues, close the coronary artery under a large incision tension, and bear a heavy load of 2 kg. By exhibiting shear-thinning and anti-swelling properties, the PEG/TA adhesive can be easily applied through single-syringe extrusion onto various wounds. The single-channel toothpaste-like feature of the adhesive ensures its storage hermetically for portable usage. Moreover, in vivo operation and histological H&E staining results indicate that the PEG/TA adhesive greatly accelerates wound healing and tissue regeneration in a rat model. With the specialty of injectability, instant self-healing, and long-lasting strong adhesion to facilitate excellent therapeutic effects, the multifunctional PEG/TA adhesive may provide a new alternative for self-rescue and surgical situations.
设计具有可注射性、自修复性和强附着力的多功能功能性医用胶粘剂对于实现理想的治疗效果以促进伤口密封在医疗保健中非常重要。本文通过多酚化合物单宁酸（TA）与带有琥珀酰亚胺戊二酸活性酯（PEG-SG）封端的八臂聚乙二醇（PEG）的物理相互作用，制备了一种自修复可注射胶粘剂。PEG 的结构单元（-CH-CH-O-）和 TA 的邻苯二酚羟基（-OH）之间的氢键以及-NHS 和-NH 之间的酯交换反应有助于自修复能力和快速强附着力。值得注意的是，PEG/TA 胶粘剂可以反复粘附到坚硬的猪组织上，在大切口张力下闭合冠状动脉，并承受 2 公斤的重负载。PEG/TA 胶粘剂通过表现出剪切稀化和抗肿胀特性，可通过单注射器挤压轻松应用于各种伤口。胶粘剂的单通道牙膏状特征确保其可密封储存，便于携带使用。此外，体内操作和组织学 H&E 染色结果表明，PEG/TA 胶粘剂在大鼠模型中大大加速了伤口愈合和组织再生。具有可注射性、即时自修复性和持久的强附着力，可实现出色的治疗效果，多功能 PEG/TA 胶粘剂可为自救和手术情况提供新的选择。
