College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
Department of General Surgery, Fuzhou General Teaching Hospital, Fujian University of Traditional Chinese Medicine (900TH Hospital of Joint Logistics Support Force), Fuzhou 35025, China.
Acta Biomater. 2024 Oct 15;188:103-116. doi: 10.1016/j.actbio.2024.08.049. Epub 2024 Sep 5.
Traditional adhesive hydrogels perform well in tissue adhesion but they fail to prevent postoperative tissue adhesion. To address this challenge, a biodegradable Janus adhesive hydrogel (J-AH) was designed and fabricated by the assembly of three different functional layers including anti-adhesive layer, reinforceable layer, and wet tissue adhesive layer. Each layer of J-AH serves a specific function: the top zwitterionic polymeric anti-adhesive layer shows superior resistance to cell/protein and tissue adhesion; the middle poly(vinyl alcohol)/tannic acid reinforceable matrix layer endows the hydrogel with good mechanical toughness of ∼2.700 MJ/m; the bottom poly(acrylic acid)/polyethyleneimine adhesive layer imparts tough adhesion (∼382.93 J/m of interfacial toughness) to wet tissues. In the rat liver and femoral injury models, J-AH could firmly adhere to the bleeding tissues to seal the wounds and exhibit impressive hemostatic efficiency. Moreover, in the in vivo adhesion/anti-adhesion assay of J-AH between the defected cecum and peritoneal walls, the top anti-adhesive layer can effectively inhibit undesired postoperative abdominal adhesion and inflammatory reaction. Therefore, this research may present a new strategy for the design of advanced bio-absorbable Janus adhesive hydrogels with multi-functions including tissue adhesion, anti-postoperative adhesion and biodegradation. STATEMENT OF SIGNIFICANCE: Despite many adhesive hydrogels with tough tissue adhesion capability have been reported, their proclivity for undesired postoperative adhesion remains a serious problem. The postoperative adhesion may lead to major complications and even endanger the lives of patients. The injectable hydrogels can cover the irregular wound and suppress the formation of postoperative adhesion. However, due to the lack of adhesive properties with tissue, it is difficult for the hydrogels to maintain on the wound surface, resulting in poor anti-postoperative adhesion effect. Herein, we design a Janus adhesive hydrogel (J-AH). J-AH integrates together robust wet tissue adhesion and anti-postoperative adhesion. Therefore, this research may present a new strategy for the design of advanced bio-absorbable Janus adhesive hydrogels.
传统的黏附性水凝胶在组织黏附中表现良好，但它们无法防止术后组织黏附。为了解决这一挑战，设计并制备了一种可生物降解的两性离子黏附水凝胶（J-AH），它由包括抗黏附层、可增强层和湿组织黏附层在内的三个不同功能层组装而成。J-AH 的每一层都有特定的功能：顶层两性离子聚合物抗黏附层表现出对细胞/蛋白质和组织黏附的优异抗性；中层聚乙烯醇/单宁酸可增强基质层赋予水凝胶良好的机械韧性（约 2.700 MJ/m）；底层聚丙烯酸/聚乙烯亚胺黏附层使水凝胶对湿组织具有坚韧的黏附性（约 382.93 J/m 的界面韧性）。在大鼠肝脏和股骨损伤模型中，J-AH 可以牢固地黏附在出血组织上以密封伤口，并表现出令人印象深刻的止血效率。此外，在 J-AH 缺陷的盲肠和腹膜壁之间的体内黏附/抗黏附实验中，顶层抗黏附层可以有效地抑制术后不必要的腹部黏附和炎症反应。因此，这项研究可能为设计具有组织黏附、抗术后黏附和生物降解等多种功能的先进可生物吸收两性离子黏附水凝胶提供一种新策略。
