Lahita R G
Cornell Medical College, New York, New York.
Psychoneuroendocrinology. 1988;13(5):385-96. doi: 10.1016/0306-4530(88)90045-5.
Systemic lupus erythematosus (SLE) is a multisystemic disease that predominates in women during the childbearing years. One system frequently affected is the central nervous system. Seizures and psychoses are criteria useful in the diagnosis of SLE. The effects of this disease on disorders of learning and handedness in both patients and first degree relatives are the subject of the present report. Dyslexia and other disorders of learning were present in 45% (24/55) of male offspring of female SLE patients. Ten percent of male siblings of female SLE patients were learning-impaired. Dyslexia and other disorders of learning are also common in women with SLE (dyslexia 12.5%) and men with SLE where the proband is one of two or more cases of SLE in the same family (dyslexia 27.6%). Tests for handedness in the lupus population indicated that there were slightly more patients (mostly women) (p = 0.08) who were lefthanded by the Oldfield laterality test compared to normal volunteers. Handedness did not correlate with the degree of dyslexia in either the patients or their first degree relatives.
系统性红斑狼疮（SLE）是一种多系统疾病，在育龄女性中更为常见。中枢神经系统是常受影响的系统之一。癫痫发作和精神病是SLE诊断中的有用标准。本文报告了该疾病对患者及其一级亲属学习障碍和利手性的影响。女性SLE患者的男性后代中，45%（24/55）存在阅读障碍和其他学习障碍。女性SLE患者的男性同胞中，10%存在学习障碍。阅读障碍和其他学习障碍在SLE女性患者（阅读障碍12.5%）以及先证者为同一家族中两例或更多SLE病例之一的SLE男性患者中（阅读障碍27.6%）也很常见。对狼疮患者群体的利手性测试表明，与正常志愿者相比，通过奥尔德菲尔德利手性测试判定为左利手的患者（大多为女性）略多（p = 0.08）。患者及其一级亲属的利手性与阅读障碍程度均无相关性。
