Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States of America.
Phys Med Biol. 2020 Mar 20;65(6):065007. doi: 10.1088/1361-6560/ab7686.
For external irradiation, the variability in organ dose estimation found between computational phantom generations arises particularly from the differences in organ positioning. This work represents the first effort to quantify the differences in organ depth below the body surface between a stylized and voxel phantom series. Herein, the revised Oak Ridge National Laboratory stylized phantom series and the University of Florida/National Cancer Institute voxel phantom series were compared. Both series include whole-body models of the newborn; the 1-, 5-, 10-, and 15-year-old; and the adult human. Organ depths from eight different directions applicable to external irradiation geometries were computed: antero-posterior, postero-anterior, left and right lateral, rotational, isotropic, cranial and caudal directions. Organ depths in the stylized phantoms were computed using a ray-tracing technique available through Monte Carlo radiation transport simulations in MCNP6. Organ depths in the voxel phantom were found using phantom matrix manipulation. Resultant organ depths for both series were plotted as distributions; available are twenty-four organs and two bone tissue distributions for each of six phantom ages and in each of the eight directional geometries. Quantitative data descriptors (e.g. mean and median depths) were also tabulated. For demonstration purposes, a literature review of relevant stylized versus voxel comparison works was performed to explore where the quantification of organ depth differences can provide further insight or evidence to study conclusions. The entire dataset of organ depth distributions and their data descriptors can be found in online supplementary files.
对于外部照射,在计算体模代际之间发现的器官剂量估计的可变性主要源于器官定位的差异。这项工作代表了首次定量研究体模系列中器官深度在体表下方的差异。在此,对修订后的橡树岭国家实验室(Oak Ridge National Laboratory)典型体模系列和佛罗里达大学/国家癌症研究所(University of Florida/National Cancer Institute)体素体模系列进行了比较。这两个系列都包括新生儿、1 岁、5 岁、10 岁和 15 岁以及成人的全身模型。计算了适用于外部照射几何形状的八个不同方向的器官深度:前后、后前、左右、旋转、各向同性、颅侧和尾侧方向。典型体模中的器官深度是通过在 MCNP6 中使用蒙特卡罗辐射传输模拟提供的射线追踪技术计算的。体素体模中的器官深度是通过体模矩阵操作找到的。两个系列的器官深度都以分布的形式表示;每个六个体模年龄和八个方向的几何图形中,都有二十四个器官和两种骨骼组织分布。还列出了定量数据描述符(例如,平均深度和中位数深度)。为了说明问题,对相关典型体模与体素比较作品进行了文献综述,以探讨器官深度差异的定量评估可以为研究结论提供进一步的见解或证据。器官深度分布及其数据描述符的整个数据集可以在在线补充文件中找到。