Suppr超能文献

中子放射生物学与剂量测定法

Neutron Radiobiology and Dosimetry.

作者信息

Stricklin Daniela L, VanHorne-Sealy Jama, Rios Carmen I, Scott Carnell Lisa A, Taliaferro Lanyn P

机构信息

Previously - Arlington Division, Applied Research Associates, Inc., Arlington.

Army Reactor Program, United States Army Nuclear and Countering Weapons of Mass Destruction Agency (USANCA), Department of Defense, Fort Belvoir, Virginia.

出版信息

Radiat Res. 2021 May 1;195(5):480-496. doi: 10.1667/RADE-20-00213.1.

Abstract

As the U.S. prepares for the possibility of a radiological or nuclear incident, or anticipated lunar and Mars missions, the exposure of individuals to neutron radiation must be considered. More information is needed on how to determine the neutron dose to better estimate the true biological effects of neutrons and mixed-field (i.e., neutron and photon) radiation exposures. While exposure to gamma-ray radiation will cause significant health issues, the addition of neutrons will likely exacerbate the biological effects already anticipated after radiation exposure. To begin to understand the issues and knowledge gaps in these areas, the National Institute of Allergy and Infectious Diseases (NIAID), Radiation Nuclear Countermeasures Program (RNCP), Department of Defense (DoD), Defense Threat Reduction Agency (DTRA), and National Aeronautics and Space Administration (NASA) formed an inter-agency working group to host a Neutron Radiobiology and Dosimetry Workshop on March 7, 2019 in Rockville, MD. Stakeholder interests were clearly positioned, given the differences in the missions of each agency. An overview of neutron dosimetry and neutron radiobiology was included, as well as a historical overview of neutron exposure research. In addition, current research in the fields of biodosimetry and diagnostics, medical countermeasures (MCMs) and treatment, long-term health effects, and computational studies were presented and discussed.

摘要

在美国为可能发生的放射性或核事件做准备,或预期开展月球和火星任务时,必须考虑个人受到中子辐射的情况。关于如何确定中子剂量以更好地估计中子及混合场(即中子和光子)辐射暴露的真实生物学效应,还需要更多信息。虽然暴露于伽马射线辐射会导致严重的健康问题,但中子的加入可能会加剧辐射暴露后已预期的生物学效应。为了开始了解这些领域的问题和知识空白,美国国立过敏与传染病研究所(NIAID)、辐射与核对策项目(RNCP)、国防部(DoD)、国防威胁降低局(DTRA)和美国国家航空航天局(NASA)成立了一个跨部门工作组,于2019年3月7日在马里兰州罗克维尔举办了一次中子放射生物学和剂量测定研讨会。鉴于各机构任务的差异,相关利益方的利益得到了明确界定。会议内容包括中子剂量测定和中子放射生物学的概述,以及中子暴露研究的历史概述。此外,还介绍并讨论了生物剂量测定与诊断、医学对策(MCMs)与治疗、长期健康影响以及计算研究等领域的当前研究情况。

相似文献

1
Neutron Radiobiology and Dosimetry.
Radiat Res. 2021 May 1;195(5):480-496. doi: 10.1667/RADE-20-00213.1.
2
Celebrating 60 Years of Accomplishments of the Armed Forces Radiobiology Research Institute1.
Radiat Res. 2021 Aug 1;196(2):129-146. doi: 10.1667/21-00064.1.
3
Analytical and quasi-Bayesian methods as development of the iterative approach for mixed radiation biodosimetry.
Radiat Environ Biophys. 2018 Aug;57(3):195-203. doi: 10.1007/s00411-018-0745-6. Epub 2018 Jun 4.
4
Accounting for neutron exposure in the Japanese atomic bomb survivors.
Radiat Res. 2014 Dec;182(6):587-98. doi: 10.1667/RR13663.1.
5
Lyoluminescence dosimetry in photon and fast neutron beams.
Phys Med Biol. 1977 Nov;22(6):1136-45. doi: 10.1088/0031-9155/22/6/006.
8
[Dosimetry of fast neutrons in 1W nuclear reactor with plastic nuclear-track detectors].
Radioisotopes. 1989 Sep;38(9):359-65. doi: 10.3769/radioisotopes.38.9_359.

引用本文的文献

3
Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.
Adv Sci (Weinh). 2024 Nov;11(42):e2401415. doi: 10.1002/advs.202401415. Epub 2024 Jul 4.
4
Minimum reporting standards should be expected for preclinical radiobiology irradiators and dosimetry in the published literature.
Int J Radiat Biol. 2024;100(1):1-6. doi: 10.1080/09553002.2023.2250848. Epub 2023 Sep 11.
6
Biomarker integration for improved biodosimetry of mixed neutron + photon exposures.
Sci Rep. 2023 Jul 6;13(1):10936. doi: 10.1038/s41598-023-37906-3.
7
Validation of a High-Throughput Dicentric Chromosome Assay Using Complex Radiation Exposures.
Radiat Res. 2023 Jan 1;199(1):1-16. doi: 10.1667/RADE-22-00007.1.
9
Acute, Low-Dose Neutron Exposures Adversely Impact Central Nervous System Function.
Int J Mol Sci. 2021 Aug 21;22(16):9020. doi: 10.3390/ijms22169020.
10
Radiation on Earth or in Space: What Does It Change?
Int J Mol Sci. 2021 Apr 3;22(7):3739. doi: 10.3390/ijms22073739.

本文引用的文献

1
Effects of single-dose protons or oxygen ions on function and structure of the cardiovascular system in male Long Evans rats.
Life Sci Space Res (Amst). 2020 Aug;26:62-68. doi: 10.1016/j.lssr.2020.04.002. Epub 2020 May 22.
4
Stylized versus voxel phantoms: a juxtaposition of organ depth distributions.
Phys Med Biol. 2020 Mar 20;65(6):065007. doi: 10.1088/1361-6560/ab7686.
6
Dose coefficients of percentile-specific computational phantoms for photon external exposures.
Radiat Environ Biophys. 2020 Mar;59(1):151-160. doi: 10.1007/s00411-019-00818-w. Epub 2019 Nov 2.
8
Radiation: a poly-traumatic hit leading to multi-organ injury.
Cell Biosci. 2019 Mar 12;9:25. doi: 10.1186/s13578-019-0286-y. eCollection 2019.
10

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验