Sütő Balázs, Kun József, Bagoly Teréz, Németh Timea, Pintér Erika, Kardos Dorottya, Helyes Zsuzsanna
Department of Anaesthesia and Intensive Therapy, Medical School, University of Pécs, 7624 Pécs, Hungary.
Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, 7624 Pécs, Hungary.
J Clin Med. 2024 Aug 12;13(16):4727. doi: 10.3390/jcm13164727.
: Stimulated capsaicin-sensitive peptidergic sensory nerves release somatostatin (SST), which has systemic anti-inflammatory and analgesic effects, correlating with the severity of tissue injury. Previous studies suggest that SST release into the systemic circulation is likely to serve as a protective mechanism during thoracic and orthopedic surgeries, scoliosis operations, and septic conditions, all involving significant tissue damage, pain, and inflammation. In a severe systemic inflammation rat model, SST released from sensory nerves into the bloodstream enhanced innate defense, reducing mortality. Inflammation is the key pathophysiological process responsible for the formation, progression, instability, and healing of atherosclerotic plaques. : We measured SST-like immunoreactivity (SST-LI) in the plasma of healthy volunteers in different age groups and also that of stable angina patients with coronary heart disease (CHD) using ELISA and tracked changes during invasive coronary interventions (coronarography) with and without stent implantation. Samples were collected at (1) pre-intervention, (2) after coronarography, (3) 2 h after coronarography initiation and coronary stent placement, and (4) the next morning. : There was a strong negative correlation between SST-LI concentrations and age; the plasma SST-LI of older healthy volunteers (47-73 years) was significantly lower than in young ones (24-27 years). Baseline SST-LI in CHD patients who needed stents was significantly reduced compared to those not requiring stents. Plasma SST-LI significantly increased two hours post stent insertion and the next morning compared to pre-intervention levels. : Age-related SST decrease might be a consequence of lower gene expression within specific hypo-thalamic nuclei as has been previously demonstrated in rodent animals. Reperfusion of ischemic myocardium post-stent implantation may trigger SST release, potentially offering protective benefits in coronary heart disease. Investigating this SST-mediated mechanism could offer valuable insights for future therapies.
辣椒素敏感的肽能感觉神经受刺激后会释放生长抑素（SST），其具有全身抗炎和镇痛作用，与组织损伤的严重程度相关。先前的研究表明，在胸外科手术、骨科手术、脊柱侧弯手术以及脓毒症等所有涉及严重组织损伤、疼痛和炎症的情况下，SST释放到体循环中可能是一种保护机制。在严重全身炎症大鼠模型中，感觉神经释放到血液中的SST增强了先天防御能力，降低了死亡率。炎症是动脉粥样硬化斑块形成、进展、不稳定和愈合的关键病理生理过程。我们使用酶联免疫吸附测定法（ELISA）测量了不同年龄组健康志愿者以及冠心病稳定型心绞痛患者血浆中的生长抑素样免疫反应性（SST-LI），并追踪了在有或无支架植入的侵入性冠状动脉介入治疗（冠状动脉造影）期间的变化。在以下时间点采集样本：（1）干预前；（2）冠状动脉造影后；（3）冠状动脉造影开始及冠状动脉支架置入后2小时；（4）第二天早晨。SST-LI浓度与年龄之间存在强烈的负相关；年龄较大的健康志愿者（47 - 73岁）血浆中的SST-LI明显低于年轻志愿者（24 - 27岁）。与不需要支架的冠心病患者相比；需要支架的冠心病患者的基线SST-LI明显降低。与干预前水平相比，支架置入后2小时及第二天早晨血浆SST-LI显著升高。与年龄相关的SST降低可能是下丘脑特定核团内基因表达降低的结果，这一点先前已在啮齿动物中得到证实。支架植入后缺血心肌的再灌注可能触发SST释放，这可能对冠心病具有潜在的保护作用。研究这种SST介导的机制可能为未来的治疗提供有价值的见解。
