Internal Medicine Department, Division of Infectious Diseases, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico Milano, 20122 Milano, Italy.
Division of Infectious Diseases and International Health, Duke University, Durham, NC 27710, USA.
Int J Mol Sci. 2020 Feb 12;21(4):1221. doi: 10.3390/ijms21041221.
Respiratory infections pose a significant threat to the success of solid organ transplantation, and the diagnosis and management of these infections are challenging. The current narrative review addressed some of these challenges, based on evidence from the literature published in the last 20 years. Specifically, we focused our attention on (i) the obstacles to an etiologic diagnosis of respiratory infections among solid organ transplant recipients, (ii) the management of bacterial respiratory infections in an era characterized by increased antimicrobial resistance, and (iii) the development of antimicrobial stewardship programs dedicated to solid organ transplant recipients.
呼吸道感染对实体器官移植的成功构成重大威胁，这些感染的诊断和管理具有挑战性。本综述性叙述基于过去 20 年发表的文献中的证据，探讨了其中的一些挑战。具体而言，我们专注于：(i) 实体器官移植受者呼吸道感染病因诊断的障碍，(ii) 耐抗生素细菌引起的呼吸道感染的管理，以及 (iii) 制定专门针对实体器官移植受者的抗菌药物管理计划。
