Bender B S, Davidson B L, Kline R, Brown C, Quinn T C
Division of Infectious Diseases, University of Florida College of Medicine, Gainesville.
Rev Infect Dis. 1988 Nov-Dec;10(6):1142-54. doi: 10.1093/clinids/10.6.1142.
In studies aimed at defining monocyte and macrophage function in patients with human immunodeficiency virus (HIV) infection, we found impaired in vivo Fc receptor-specific clearance in 20 of 25 patients with acquired immunodeficiency syndrome (AIDS) and in five of 13 patients with AIDS-related illnesses. The in vivo function of macrophage C3 receptors was also found to be abnormal: AIDS patients had a relatively large release of cell back into the circulation, suggesting failure of macrophage phagocytosis. The antibody-dependent cell-mediated cytotoxicity of circulating mononuclear cells was significantly lower in AIDS patients than in healthy controls. Monocyte nonspecific phagocytosis and surface marker expression were intact. Defective monocyte and macrophage function is an integral part of the immunopathology of AIDS, leading to the failure to control opportunistic pathogens. Whether these defects are due to intrinsic infection of the mononuclear phagocytes with HIV or are secondary to other events in the network of HIV infection remains to be determined.
在旨在明确人类免疫缺陷病毒（HIV）感染患者体内单核细胞和巨噬细胞功能的研究中，我们发现，25例获得性免疫缺陷综合征（AIDS）患者中有20例以及13例艾滋病相关疾病患者中有5例存在体内Fc受体特异性清除功能受损的情况。巨噬细胞C3受体的体内功能也被发现异常：艾滋病患者有相对大量的细胞释放回循环系统，提示巨噬细胞吞噬功能存在缺陷。艾滋病患者循环单核细胞的抗体依赖性细胞介导的细胞毒性显著低于健康对照。单核细胞的非特异性吞噬作用和表面标志物表达保持完整。单核细胞和巨噬细胞功能缺陷是艾滋病免疫病理学的一个组成部分，导致无法控制机会性病原体。这些缺陷是由于单核吞噬细胞被HIV内在感染，还是继发于HIV感染网络中的其他事件，仍有待确定。
