Randolph Michael J, Salhi Waleed Al, Tosti Antonella
University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Dermatology, College of Medicine, Majmaah University, Al-Majmaah, 11952, Saudi Arabia.
Dermatol Ther (Heidelb). 2020 Apr;10(2):311-319. doi: 10.1007/s13555-020-00359-x. Epub 2020 Feb 14.
Lichen planopilaris (LPP) is a cell-mediated scarring alopecia that causes inflammation of the scalp and the eventual destruction of hair follicles in affected areas. Current literature on treatment of LPP remains limited with no definitive treatment approach being recognized, although a combination of topical/intralesional steroids and orally administered hydroxychloroquine remains the most utilized option. Low-level light therapy (LLLT) is an expanding technology shown to be effective in a variety of dermatologic conditions. We report here four patients with LPP who show a dramatic response to LLLT, including a reduction of inflammation, disappearance of symptoms, and evident hair regrowth with no side effects. We review the possible role of LLLT in LPP and other lichenoid conditions.
扁平苔藓样毛发角化病（LPP）是一种细胞介导的瘢痕性脱发，可导致头皮炎症以及受累区域毛囊的最终破坏。尽管外用/皮损内注射类固醇与口服羟氯喹联合使用仍是最常用的治疗方法，但目前关于LPP治疗的文献仍然有限，尚无明确的治疗方法得到认可。低能量激光疗法（LLLT）是一项不断发展的技术，已证明在多种皮肤病中有效。我们在此报告4例LPP患者，他们对LLLT有显著反应，包括炎症减轻、症状消失以及明显的毛发再生且无副作用。我们回顾了LLLT在LPP和其他苔藓样疾病中的可能作用。
