Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Adv Exp Med Biol. 2020;1231:33-43. doi: 10.1007/978-3-030-36667-4_4.
The tumor microenvironment is the primary location in which tumor cells and the host immune system interact. There are many physiological, biochemical, cellular mechanisms in the neighbor of tumor which is composed of various cell types. Interactions of chemokines and chemokine receptors can recruit immune cell subsets into the tumor microenvironment. These interactions can modulate tumor progression and metastasis. In this chapter, we will focus on chemokine (C-C motif) ligand 7 (CCL7) that is highly expressed in the tumor microenvironment of various cancers, including colorectal cancer, breast cancer, oral cancer, renal cancer, and gastric cancer. We reviewed how CCL7 can affect cancer immunity and tumorigenesis by describing its regulation and roles in immune cell recruitment and stromal cell biology.
肿瘤微环境是肿瘤细胞和宿主免疫系统相互作用的主要场所。肿瘤的周围有许多生理、生化和细胞机制，由各种细胞类型组成。趋化因子及其受体的相互作用可以招募免疫细胞亚群进入肿瘤微环境。这些相互作用可以调节肿瘤的进展和转移。在本章中，我们将重点介绍趋化因子（C-C 基序）配体 7（CCL7），它在包括结直肠癌、乳腺癌、口腔癌、肾癌和胃癌在内的各种癌症的肿瘤微环境中高度表达。我们通过描述 CCL7 在招募免疫细胞和基质细胞生物学方面的调节和作用，综述了它如何影响癌症免疫和肿瘤发生。
