Yi Qiang, Zhu Gangfeng, Zhu Weijian, Wang Jiaqi, Ouyang Xinting, Yang Kuan, Fan Yu, Zhong Jinghua
The First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi Province, 341000, China.
Department of Oncology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, 341000, China.
Heliyon. 2024 Sep 7;10(18):e37527. doi: 10.1016/j.heliyon.2024.e37527. eCollection 2024 Sep 30.
LINC01094 is a long non-coding RNA that plays a crucial role in cancer progression by modulating key signaling pathways, such as PI3K/AKT, Wnt/β-catenin and TGF-β Signaling Pathway Feedback Loop. In this review we summarize the recent research on the functional mechanisms of LINC01094 in various cancers, including its impact on tumor growth, metastasis, and resistance to therapy. We also discuss the therapeutic potential of targeting LINC01094 and highlight the current strategies and challenges in this area. Perspectives on future development of LINC01094-based therapies are also provided.
LINC01094是一种长链非编码RNA，它通过调节关键信号通路（如PI3K/AKT、Wnt/β-连环蛋白和TGF-β信号通路反馈环）在癌症进展中发挥关键作用。在这篇综述中，我们总结了近期关于LINC01094在各种癌症中的功能机制的研究，包括其对肿瘤生长、转移和治疗耐药性的影响。我们还讨论了靶向LINC01094的治疗潜力，并强调了该领域当前的策略和挑战。此外，还提供了基于LINC01094的治疗方法未来发展的展望。
