CCL20 在肿瘤微环境中的信号转导作用。
CCL20 Signaling in the Tumor Microenvironment.
机构信息
Fudan University Shanghai Cancer Center & Institutes of Biomedical Sciences, Shanghai Medical College, Shanghai, China.
Key Laboratory of Breast Cancer in Shanghai, Innovation Center for Cell Signaling Network, Cancer Institute, Shanghai, China.
出版信息
Adv Exp Med Biol. 2020;1231:53-65. doi: 10.1007/978-3-030-36667-4_6.
CCL20, as a chemokine, plays an important role in rheumatoid arthritis, psoriasis, and other diseases by binding to its receptor CCR6. Recent 10 years' research has demonstrated that CCL20 also contributes to the progression of many cancers, such as liver cancer, colon cancer, breast cancer, pancreatic cancer, and gastric cancer. This article reviews and discusses the previous studies on CCL20 roles in cancers from the aspects of its specific effects on various cancers, its remodeling on tumor microenvironment (TME), its synergistic effects with other cytokines in tumor microenvironment, and the specific mechanisms of CCL20 signal activation, illustrating CCL20 signaling in TME from multiple directions.
趋化因子 CCL20 通过与其受体 CCR6 结合，在类风湿关节炎、银屑病和其他疾病中发挥重要作用。最近 10 年的研究表明，CCL20 也有助于许多癌症的进展，如肝癌、结肠癌、乳腺癌、胰腺癌和胃癌。本文从 CCL20 对各种癌症的具体作用、对肿瘤微环境（TME）的重塑作用、与 TME 中的其他细胞因子的协同作用以及 CCL20 信号激活的具体机制等方面，对 CCL20 在癌症中的作用进行了综述和讨论，从多个方向阐述了 CCL20 在 TME 中的信号转导。
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