Departments of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Departments of Dermatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Adv Exp Med Biol. 2020;1240:95-110. doi: 10.1007/978-3-030-38315-2_8.
The ability of the immune system to prevent or control the growth of tumor cells is critically dependent on inflammatory processes that lead to the activation, expansion, and recruitment of antitumor effector cells into the tumor microenvironment (TME). These processes are orchestrated by soluble cytokines produced in tissues that alarm local immune surveillance cells (such as dendritic cells, DCs) to mobilize protective antitumor immune populations (B cells, T cells). The interleukin (IL)-36 family of pro-inflammatory cytokines plays an important role in multiple disease processes, ranging from an instigator of autoimmune psoriasis to an initiator of therapeutic immune responses against tumor cells. This chapter will focus on the biologic role of immunomodulatory IL-36 family cytokines in the cancer setting and their potential utility in the design of effective interventional therapies. (127 words).
免疫系统预防或控制肿瘤细胞生长的能力严重依赖于炎症过程，这些过程导致抗肿瘤效应细胞在肿瘤微环境（TME）中的激活、扩增和募集。这些过程由组织中产生的可溶性细胞因子协调，这些细胞因子可以警示局部免疫监视细胞（如树突状细胞[DCs]）动员保护性抗肿瘤免疫细胞群（B 细胞、T 细胞）。白细胞介素（IL）-36 家族促炎细胞因子在多种疾病过程中发挥重要作用，从引发自身免疫性银屑病到启动针对肿瘤细胞的治疗性免疫反应。本章将重点介绍免疫调节 IL-36 家族细胞因子在癌症环境中的生物学作用及其在设计有效干预治疗中的潜在用途。（127 个单词）。
