Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Int J Dermatol. 2020 May;59(5):595-598. doi: 10.1111/ijd.14820. Epub 2020 Feb 14.
Voriconazole and genus beta human papillomavirus (HPV) are independently associated with the development of photo-exposed cutaneous squamous cell carcinoma (SCC) but have not been evaluated concurrently. The objective of this study is to determine the prevalence and type of detectable HPV DNA in voriconazole-associated SCC.
SCCs from immunosuppressed patients, in those with and without voriconazole exposure, were evaluated by PCR analysis for HPV DNA and compared to SCC from non-immunosuppressed patients. An additional expanded PCR analysis of all SCC that developed in the voriconazole group was also performed.
HPV DNA was detected by PCR in all groups regardless of the immunosuppression status (80.5%) with beta HPV most prevalent (64.3-78.6%). However, immunosuppressed patients were significantly more likely to be infected by beta HPV types 5, 8, 14, 20, and 21 (P-value 0.014), and represented the majority of beta HPV types found in the voriconazole group.
In this retrospective study, beta HPV 5, 8, 14, 20, and 21 were commonly detected in voriconazole-associated SCC. The results indicate a possible role of beta HPV in the pathogenesis of cutaneous SCC in photo-exposed areas. Further studies are needed to establish the role of HPV and voriconazole in the pathogenesis of the lesion.
伏立康唑和β 型人乳头瘤病毒（HPV）均与光暴露皮肤鳞状细胞癌（SCC）的发生独立相关，但尚未同时进行评估。本研究旨在确定伏立康唑相关 SCC 中可检测 HPV DNA 的流行率和类型。
通过 PCR 分析评估有和无伏立康唑暴露的免疫抑制患者的 SCC 中 HPV DNA 的存在情况，并与非免疫抑制患者的 SCC 进行比较。还对伏立康唑组中所有发生的 SCC 进行了额外的扩展 PCR 分析。
无论免疫抑制状态如何（80.5%），所有组均通过 PCR 检测到 HPV DNA，β HPV 最为常见（64.3%-78.6%）。然而，免疫抑制患者更有可能感染β HPV 型 5、8、14、20 和 21（P 值 0.014），并且代表了伏立康唑组中发现的大多数β HPV 型。
在这项回顾性研究中，伏立康唑相关 SCC 中常见检测到β HPV 5、8、14、20 和 21。结果表明β HPV 可能在光暴露区域皮肤 SCC 的发病机制中起作用。需要进一步的研究来确定 HPV 和伏立康唑在病变发病机制中的作用。
