Department of Community and Family Medicine and The Norris Cotton Cancer Center, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, One Medical Center Drive, Lebanon, NH 03756, USA.
Int J Cancer. 2013 Oct 1;133(7):1713-20. doi: 10.1002/ijc.28176. Epub 2013 Apr 22.
Human papillomavirus (HPV) infection is common worldwide and, in immunodeficient populations, may contribute to the pathogenesis of keratinocyte cancers, particularly squamous cell carcinomas (SCC). However, their role in SCC in the general population is less clear. We conducted a comprehensive analysis to investigate the independent effects of seropositivity for cutaneous alpha, beta and gamma HPV types on risk of SCC, and a meta-analysis of the available literature. In a population-based case-control study from New Hampshire, USA (n = 1,408), histologically confirmed SCC cases and controls were tested for L1 antibodies to alpha, beta and gamma cutaneous HPV types 2-5, 7-10, 15, 17, 20, 23, 24, 27b, 36, 38, 48-50, 57, 65, 75-77, 88, 92, 95, 96, 101, 103 and 107 using multiplex serology. An increasing risk of SCC with number of beta HPVs to which an individual tested positive was observed even among those seronegative for gamma types (p for trend = 0.016) with an odds ratio of 1.95 (95% confidence interval (CI) = 1.07-3.56) for four or more beta types positive. In a meta-analysis of six case-control studies, increased SCC risks in relation to beta HPV seropositivity were found across studies (meta odds ratio = 1.45, CI = 1.27-1.66). While the prevalence of gamma HPVs assayed was somewhat higher among SCC cases than controls, the association was only weakly evident among those seronegative for beta HPVs. Overall, the association between cutaneous HPVs and skin cancers appears to be specific to SCC and to genus beta HPVs in a general US population.
人乳头瘤病毒（HPV）感染在全球范围内很常见，在免疫功能低下的人群中，可能导致角质形成细胞癌的发病机制，特别是鳞状细胞癌（SCC）。然而，它们在普通人群中 SCC 的作用尚不明确。我们进行了一项全面的分析，以研究皮肤 alpha、beta 和 gamma HPV 型别血清阳性对 SCC 风险的独立影响，并对现有文献进行了荟萃分析。在美国新罕布什尔州进行的一项基于人群的病例对照研究（n=1408）中，对组织学确诊的 SCC 病例和对照进行了 alpha、beta 和 gamma 皮肤 HPV 型 2-5、7-10、15、17、20、23、24、27b、36、38、48-50、57、65、75-77、88、92、95、96、101、103 和 107 的 L1 抗体检测，使用多重血清学方法。即使在 gamma 型别血清阴性的个体中，也观察到个体对 beta HPV 的阳性检测数量与 SCC 风险呈正相关（趋势检验 p=0.016），对 4 种或更多 beta 型阳性的比值比为 1.95（95%置信区间（CI）=1.07-3.56）。在 6 项病例对照研究的荟萃分析中，发现与 beta HPV 血清阳性相关的 SCC 风险增加在研究中存在（荟萃比值比=1.45，CI=1.27-1.66）。虽然 SCC 病例中检测到的 gamma HPV 流行率略高于对照组，但在 beta HPV 血清阴性的人群中，这种关联仅微弱存在。总体而言，在普通美国人群中，皮肤 HPV 与皮肤癌之间的关联似乎特异性地与 SCC 和 genus beta HPV 相关。
