Levine Cancer Institute, Atrium Health Wake Forest Baptist, Charlotte, NC, USA.
Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA.
Best Pract Res Clin Haematol. 2023 Jun;36(2):101464. doi: 10.1016/j.beha.2023.101464. Epub 2023 Apr 6.
Adoptive cellular immunotherapy, mainly hematopoietic stem cell transplant and CAR-T cell therapy have revolutionized treatment of patients with acute leukemia. Indications and inclusion criteria for these treatments have expanded in recent years. While these therapies are associated with significant improvements in disease response and overall survival, patients may experience adverse events from associated chemotherapy conditioning, engraftment, cytokine storm, supportive medications, and post-transplant maintenance targeted therapies. Supportive oncodermatology is a growing specialty to manage cutaneous toxicities resulting from the anti-cancer therapies. In this review, we summarize diagnosis and management of the common cutaneous adverse events including drug eruptions, graft-versus-host disease, neoplastic and paraneoplastic complications in patients undergoing cellular therapies.
过继性细胞免疫疗法，主要是造血干细胞移植和 CAR-T 细胞疗法，彻底改变了急性白血病患者的治疗方法。这些治疗方法的适应证和纳入标准近年来有所扩大。虽然这些疗法与疾病反应和总体生存率的显著改善相关，但患者可能会因相关化疗预处理、植入、细胞因子风暴、支持性药物和移植后维持靶向治疗而出现不良事件。支持性肿瘤皮肤科是一个不断发展的专业领域，可治疗癌症治疗引起的皮肤毒性。在这篇综述中，我们总结了接受细胞治疗的患者中常见的皮肤不良事件的诊断和管理，包括药物反应、移植物抗宿主病、肿瘤和副肿瘤并发症。
