全氟辛烷磺酸和/或全氟辛酸及其遗留水成膜泡沫对日本鹌鹑（Coturnix japonica）雏鸡的亚急性毒性。
The Subacute Toxicity of Perfluorooctane Sulfonate and/or Perfluorooctanoic Acid and Legacy Aqueous Film-Forming Foams to Japanese Quail (Coturnix japonica) Chicks.
机构信息
Department of Animal Science, Michigan State University, East Lansing, Michigan, USA.
Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.
出版信息
Environ Toxicol Chem. 2021 Mar;40(3):695-710. doi: 10.1002/etc.4684. Epub 2020 Mar 31.
As part of an effort to develop avian ecotoxicity information for poly- and perfluoroalkyl substances (PFAS) including perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) associated with aqueous film-forming foam (AFFF) used by the Department of Defense, the subacute toxicity of PFOS, PFOA, PFOS + PFOA, 3M AFFF, and Ansul AFFF to Japanese quail (Coturnix japonica) chicks was determined. Ten-day-old Japanese quail were administered treated feed for 5 d and then fed untreated feed for 18 d. Analyzed concentrations of PFOS, PFOA, and PFOS + PFOA ranged from 62 to 1955, 162 to 1208, and 43 + 45 to 296 + 292 mg kg feed . Analyzed concentrations of PFOS in feed containing the 3M AFFF ranged from 73 to 1399 mg kg feed , and formulated concentrations of 6:2 fluorotelomer thioamido sulfonate in feed containing the Ansul AFFF ranged from 9 to 1118 mg kg feed . Average daily doses resulting in 50% mortality at day 5 were 38 (34-43), 68 (63-74), 55 (51-59), and 130 (103-164) mg PFOS, PFOA, PFOS + PFOA, and PFOS in 3M AFFF kg body weight d . Ansul AFFF did not result in any mortalities. Dietary concentrations resulting in 50% mortality at day 5 were 351 (275-450), 496 (427-575), 398 (339-468), and 467 (390-559) mg PFOS, PFOA, PFOS + PFOA, and PFOS in 3M AFFF kg feed . Environ Toxicol Chem 2021;40:695-710. © 2020 SETAC.
作为开发与用于国防部的水性成膜泡沫（AFFF）相关的多氟和全氟烷基物质（PFAS），包括全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的鸟类生态毒性信息的工作的一部分，本研究确定了 PFOS、PFOA、PFOS+PFOA、3M AFFF 和 Ansul AFFF 对日本鹌鹑（Coturnix japonica）雏鸡的亚急性毒性。10 日龄的日本鹌鹑接受处理饲料 5 天，然后接受未处理饲料 18 天。分析得出的 PFOS、PFOA 和 PFOS+PFOA 的浓度范围分别为 62-1955、162-1208 和 43+45-296+292mg/kg 饲料。3M AFFF 中含有的 PFOS 饲料的分析浓度范围为 73-1399mg/kg 饲料，Ansul AFFF 中含有的氟调聚物硫代酰胺磺酸盐的配方浓度范围为 9-1118mg/kg 饲料。导致第 5 天 50%死亡率的平均日剂量分别为 38（34-43）、68（63-74）、55（51-59）和 130（103-164）mg PFOS、PFOA、PFOS+PFOA 和 3M AFFF 中的 PFOS/kg 体重 d。Ansul AFFF 未导致任何死亡。第 5 天导致 50%死亡率的膳食浓度分别为 351（275-450）、496（427-575）、398（339-468）和 467（390-559）mg PFOS、PFOA、PFOS+PFOA 和 3M AFFF/kg 饲料。环境毒理化学 2021；40:695-710。©2020 SETAC。
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