用于癌症早期检测的 DNA 甲基化分类器的诊断效能。
Diagnostic Power of DNA Methylation Classifiers for Early Detection of Cancer.
机构信息
Laboratory for Advanced Medicine Inc., Irvine, CA, USA.
University of Hawaii Cancer Center, Honolulu, HI, USA.
出版信息
Trends Cancer. 2020 Feb;6(2):78-81. doi: 10.1016/j.trecan.2019.12.006. Epub 2020 Feb 3.
Abstract
DNA methylation-based epigenetic signatures have become valuable cancer biomarkers. We highlight the advantages of liquid biopsy based DNA-methylation profiling for noninvasive diagnosis of early stage cancers and discuss the advanced analytical approaches developed by commercial and academic partnerships.
摘要
基于 DNA 甲基化的表观遗传特征已成为有价值的癌症生物标志物。我们强调了基于液体活检的 DNA 甲基化分析在早期癌症的无创诊断中的优势，并讨论了商业和学术合作开发的先进分析方法。
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