代谢器官中的水通道蛋白调节。

Aquaporin regulation in metabolic organs.

机构信息

Division of Gastroenterology and Hepatology, Joan & Sanford I. Weill Cornell Department of Medicine, Weill Cornell Medical College, New York, NY, United States; Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria.

出版信息

Vitam Horm. 2020;112:71-93. doi: 10.1016/bs.vh.2019.09.002. Epub 2020 Jan 28.

DOI:10.1016/bs.vh.2019.09.002

PMID:32061350

Abstract

Aquaporins (AQPs) are a family of 13 small trans-membrane proteins, which facilitate shuttling of glycerol, water and urea. The peculiar role of AQPs in glycerol transport makes them attractive targets in metabolic organs since glycerol represents the backbone of triglyceride synthesis. Importantly, AQPs are known to be regulated by various nuclear receptors which in turn govern lipid and glucose metabolism as well as inflammatory cascades. Here, we review the role of AQPs regulation in metabolic organs exploring their physiological impact in health and disease.

摘要

水通道蛋白（AQPs）是一个由 13 种小跨膜蛋白组成的家族，可促进甘油、水和尿素的转运。AQP 在甘油转运中的特殊作用使它们成为代谢器官中极具吸引力的靶标，因为甘油是甘油三酯合成的骨架。重要的是，AQP 受多种核受体调节，这些核受体反过来又控制脂质和葡萄糖代谢以及炎症级联反应。在这里，我们研究了代谢器官中 AQP 调节的作用，探讨了它们在健康和疾病中的生理影响。