School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center for Green Fine Chemicals, South China University of Technology, Guangzhou 510641, China.
School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center for Green Fine Chemicals, South China University of Technology, Guangzhou 510641, China; School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.
Int J Biol Macromol. 2020 May 15;151:421-427. doi: 10.1016/j.ijbiomac.2020.02.114. Epub 2020 Feb 12.
In this work, the anionic and cationic lignin-based drug-loaded materials (SL/CTAB) with strong hydrophobicity were prepared by using Sodium Lignosulfonate (SL) via self-assembly. The obtained SL/CTAB was used as drug-loaded material and emulsifier to prepare avermectin nano-formulation, which can be automatically dispersed into nano drug-loaded nanospheres in water. The cold and hot storage experiments show that the physical and chemical stability of the nano-formulation is good. The nano-formulation exhibits controlled-release performance, and the cumulative release amounts range from 56.27% to 87.33% in 62 h. Meanwhile, the release rates slow down with increasing SL/CTAB dosage. After UV irradiation for 50 h, the retention rates of avermectin in the nano-formulation range from 46.67% to 63.41%, which is 2.18-2.96 times higher than commercial avermectin Emulsifiable Concentrate (EC). The experiment of simulated rainwater scour-resistance shows that the affinity of lignin-based nano-formulation to the Epipremnum aureum leaves is higher than EC formulation.
在这项工作中，通过自组装，使用磺化木质素（SL）制备了具有强疏水性的阴离子型和阳离子型木质素载药材料（SL/CTAB）。将所得的 SL/CTAB 用作载药材料和乳化剂，制备阿维菌素纳米制剂，该制剂可自动分散在水中形成纳米载药纳米球。冷、热储存实验表明，纳米制剂具有良好的物理化学稳定性。纳米制剂表现出控制释放性能，在 62 小时内累积释放量范围为 56.27%至 87.33%。同时，随着 SL/CTAB 用量的增加，释放速率逐渐减慢。经 50 h 紫外线照射后，纳米制剂中阿维菌素的保留率在 46.67%至 63.41%之间，是商业阿维菌素乳油（EC）的 2.18-2.96 倍。模拟雨水冲刷阻力实验表明，木质素基纳米制剂对绿萝叶片的亲和力高于 EC 制剂。
