Univeristy of Groningen, Department of Pharmacy and Drug Design, the Netherlands.
University Medical Center Utrecht, Department of Nephrology and Hypertension, the Netherlands.
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165716. doi: 10.1016/j.bbadis.2020.165716. Epub 2020 Feb 19.
Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), also known as Rhodanese, is a mitochondrial enzyme which catalyzes the transfer of sulfur in several molecular pathways. After its initial identification as a cyanide detoxification enzyme, it was found that its functions also include sulfur metabolism, modification of iron‑sulfur clusters and the reduction of antioxidants glutathione and thioredoxin. TST deficiency was shown to be strongly related to the pathophysiology of metabolic diseases including diabetes and obesity. This review summarizes research related to the enzymatic properties and functions of TST, to then explore the association between the effects of TST on mitochondria and development of diseases such as diabetes and obesity.
硫代硫酸转硫酶（TST，EC 2.8.1.1），又称硫氰酸酶，是一种催化几种分子途径中硫转移的线粒体酶。在最初被鉴定为氰化物解毒酶后，发现其功能还包括硫代谢、铁硫簇的修饰以及抗氧化剂谷胱甘肽和硫氧还蛋白的还原。TST 缺乏与包括糖尿病和肥胖症在内的代谢疾病的病理生理学密切相关。本综述总结了与 TST 的酶学特性和功能相关的研究，然后探讨了 TST 对线粒体的影响与糖尿病和肥胖等疾病发展之间的关系。
