Department of Chemical Sciences and Technology, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.
Int J Mol Sci. 2022 Jul 30;23(15):8452. doi: 10.3390/ijms23158452.
Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron-sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme.
氰化物硫转移酶（TST），也称为硫代尿酸酶，是一种广泛分布于原核生物和真核生物中的酶，在其中它在线粒体功能中起着重要作用。TST 酶参与几种生化过程，如：氰化物解毒、生物可利用形式的硫和硒的运输、铁硫簇的恢复、氧化还原系统的维持以及 5S rRNA 的线粒体导入。最近，TST 在代谢疾病（如糖尿病）中的相关性已被强调，为研究糖尿病中硫代谢的重要方面开辟了道路。本综述强调了 TST 的结构和功能特征，描述了这种必需酶的生理作用以及生物医学和生物技术应用。
