周期性淀粉样蛋白β-星形胶质细胞活动诱导阿尔茨海默病中的氧化应激。

Cyclical amyloid beta-astrocyte activity induces oxidative stress in Alzheimer's disease.

机构信息

Laboratory of Molecular Neuroscience and Dementia, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2050, Australia.

Laboratory of Molecular Neuroscience and Dementia, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2050, Australia; Discipline of Pathology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, 2006, Australia.

出版信息

Biochimie. 2020 Apr-May;171-172:38-42. doi: 10.1016/j.biochi.2020.02.003. Epub 2020 Feb 13.

DOI:10.1016/j.biochi.2020.02.003

PMID:32061803

Abstract

Glial cell involvement in Alzheimer's disease (AD) is multi-faceted. The role of astrocytes in AD pathology, both as a causative agent of amyloid-beta (Aβ) production as well as a casualty of dysfunction resulting from the presence of Aβ has been well-delineated. In this review, we explore the influence of oxidative stress in astrocytes and the subsequent effect on Aβ levels in the brain from a perspective of intracellular calcium homeostasis and NADPH oxidase activity. The response of astrocytes to the presence of Aβ, as well astrocytic and microglial interaction and inflammatory cytokine release is also discussed, highlighting a cyclical behaviour of these cells in contributing to AD pathogenesis.

摘要

神经胶质细胞在阿尔茨海默病（AD）中的作用是多方面的。星形胶质细胞在 AD 病理中的作用，既是淀粉样蛋白-β（Aβ）产生的原因，也是由于 Aβ 存在导致功能障碍的受害者，这一点已经得到了很好的描述。在这篇综述中，我们从细胞内钙稳态和 NADPH 氧化酶活性的角度探讨了氧化应激对星形胶质细胞的影响，以及随后对大脑中 Aβ 水平的影响。还讨论了星形胶质细胞对 Aβ 的反应，以及星形胶质细胞和小胶质细胞的相互作用和炎症细胞因子的释放，强调了这些细胞在促进 AD 发病机制中的循环行为。