Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India.
Int J Pharm. 2020 Apr 15;579:119140. doi: 10.1016/j.ijpharm.2020.119140. Epub 2020 Feb 13.
Acne vulgaris is a chronic inflammatory skin disorder affecting mostly females. It has a negative impact on the social life and psychological well-being of the individual. Its pathogenesis involves an exaggerated secretion of sebum, hyperkeratinisation of hair follicles, colonization of anaerobic microbes in the hair follicles, and inflammation. Conventional therapy for acne utilizes antibacterial and anti-inflammatory drugs. Systemic use of these drugs is associated with undesirable toxicities. Hence, topical delivery of anti-acne drugs is desired. However, topical delivery is hindered by poor aqueous solubility of drug and inadequate penetration across stratum corneum. Nanocarriers are endowed with immense potential to facilitate topical delivery of anti-acne drugs as monotherapy or in combination by a myriad of mechanisms including occlusive nature promoting skin hydration, providing sustained drug release thereby decreasing dosing frequency, follicular targeting, and protecting the labile active from degradation. Further, smart nanocarriers can deliver the anti-acne cargo in response to some stimulus present at the disease site precluding undesirable effects at non target sites. Nanocarriers have also been explored in photothermal and photodynamic therapy of acne for destruction of antibiotic resistant bacteria implicated in acne. This review focuses on the potential of a variety of nanocarriers for treatment of acne.
寻常痤疮是一种影响大多数女性的慢性炎症性皮肤病。它对个体的社会生活和心理健康有负面影响。其发病机制涉及皮脂分泌过度、毛囊角化过度、毛囊内厌氧菌定植和炎症。痤疮的常规治疗采用抗菌和抗炎药物。这些药物全身使用会引起不良的毒性。因此，需要局部递送抗痤疮药物。然而，由于药物的水溶性差和角质层穿透不足，局部递送受到阻碍。纳米载体具有巨大的潜力，可以通过多种机制促进抗痤疮药物的局部递送，包括作为单一疗法或联合疗法，包括封闭性质促进皮肤水合作用、提供持续的药物释放从而减少给药频率、毛囊靶向和保护不稳定的活性物质免受降解。此外，智能纳米载体可以在疾病部位存在一些刺激物的情况下递送抗痤疮有效载荷，从而防止在非目标部位产生不良影响。纳米载体也已在痤疮的光热和光动力治疗中得到探索，以破坏与痤疮相关的抗生素耐药细菌。本文综述了各种纳米载体在治疗痤疮方面的潜力。
