Nilsson S, Marklund S L
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
Scand J Clin Lab Invest. 1988 Sep;48(5):441-4. doi: 10.1080/00365518809085754.
The secretory protein extracellular-superoxide dismutase is the major superoxide dismutase (SOD) isoenzyme in the extracellular space. There is evidence to suggest that most extracellular-superoxide dismutase in the vascular system is bound to endothelial cell surfaces. Venous stasis and physical exercise is known to induce release of several endothelium-associated factors into the plasma. However, venous stasis and physical exercise were not found to induce any release of extracellular-superoxide dismutase into plasma. The plasma activity of the intracellular isoenzyme CuZn SOD was doubled by venous stasis.
分泌性蛋白细胞外超氧化物歧化酶是细胞外空间中的主要超氧化物歧化酶（SOD）同工酶。有证据表明，血管系统中的大多数细胞外超氧化物歧化酶与内皮细胞表面结合。已知静脉淤滞和体育锻炼会诱导几种内皮相关因子释放到血浆中。然而，未发现静脉淤滞和体育锻炼会诱导细胞外超氧化物歧化酶释放到血浆中。静脉淤滞使细胞内同工酶铜锌超氧化物歧化酶的血浆活性增加了一倍。
