Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China; International Genome Center, Jiangsu University, Zhenjiang 212013, China.
International Genome Center, Jiangsu University, Zhenjiang 212013, China; Department of Immunology, Jiangsu University, Zhenjiang 212013, China.
Int Immunopharmacol. 2020 Apr;81:106277. doi: 10.1016/j.intimp.2020.106277. Epub 2020 Feb 14.
Interleukin-22 (IL-22), which belongs to the IL-10 family, is an alpha helix cytokine specifically produced by many lymphocytes, such as Th1, Th17, Th22, ILCs, CD4+ and CD8+ T cells. In recent years, more and more studies have demonstrated that IL-22 has an interesting relationship with various cardiovascular diseases, including myocarditis, myocardial infarction, atherosclerosis, and other cardiovascular diseases, and IL-22 signal may play a dual role in cardiovascular diseases. Here, we summarize the recent progress on the source, function, regulation of IL-22 and the effects of IL-22 signal in cardiovascular diseases. The study of IL-22 will suggest more specific strategies to maneuver these functions for the effective treatment of cardiovascular diseases and future clinical treatment.
白细胞介素-22（IL-22）属于白细胞介素-10 家族，是一种由多种淋巴细胞（如 Th1、Th17、Th22、ILCs、CD4+和 CD8+T 细胞）特异性产生的α螺旋细胞因子。近年来，越来越多的研究表明，IL-22 与各种心血管疾病（包括心肌炎、心肌梗死、动脉粥样硬化等）之间存在有趣的关系，IL-22 信号可能在心血管疾病中发挥双重作用。在这里，我们总结了 IL-22 的来源、功能、调节及其在心血管疾病中的作用的最新进展。对 IL-22 的研究将为有效治疗心血管疾病和未来的临床治疗提供更具体的策略来操纵这些功能。
