School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Front Immunol. 2022 May 11;13:903678. doi: 10.3389/fimmu.2022.903678. eCollection 2022.
Cardiovascular diseases (CVDs) are responsible for most pre-mature deaths worldwide, contributing significantly to the global burden of disease and its associated costs to individuals and healthcare systems. Obesity and associated metabolic inflammation underlie development of several major health conditions which act as direct risk factors for development of CVDs. Immune system responses contribute greatly to CVD development and progression, as well as disease resolution. Innate lymphoid cells (ILCs) are a family of helper-like and cytotoxic lymphocytes, typically enriched at barrier sites such as the skin, lung, and gastrointestinal tract. However, recent studies indicate that most solid organs and tissues are home to resident populations of ILCs - including those of the cardiovascular system. Despite their relative rarity, ILCs contribute to many important biological effects during health, whilst promoting inflammatory responses during tissue damage and disease. This mini review will discuss the evidence for pathological and protective roles of ILCs in CVD, and its associated risk factor, obesity.
心血管疾病（CVDs）是全球大多数早逝的罪魁祸首，对疾病的全球负担及其对个人和医疗系统的相关成本有重大影响。肥胖症和相关的代谢炎症是多种主要健康状况的基础，这些健康状况是 CVDs 发展的直接危险因素。免疫系统反应对 CVD 的发展和进展以及疾病的解决有很大贡献。先天淋巴细胞（ILCs）是一类辅助样和细胞毒性淋巴细胞，通常在皮肤、肺和胃肠道等屏障部位富集。然而，最近的研究表明，大多数实体器官和组织都存在 ILCs 的常驻群体，包括心血管系统。尽管它们相对较少，但 ILCs 在健康期间有助于许多重要的生物学效应，同时在组织损伤和疾病期间促进炎症反应。这篇小型综述将讨论 ILCs 在 CVD 及其相关危险因素肥胖症中的病理和保护作用的证据。
