Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Chemosphere. 2020 Jun;249:126120. doi: 10.1016/j.chemosphere.2020.126120. Epub 2020 Feb 6.
We examined the main effects of ambient particulate matters, as well as whether single-nucleotide polymorphisms (SNPs), located within ABO gene would modify the relationship. Data were collected from a family-based study conducted in Northern China. A generalized additive model with a Gaussian link and with each family as a stratum was applied to estimate the percentage change in blood lipid levels following a 10 μg/m increase in ambient particulate matter concentrations. Interaction analyses were conducted by including a cross-product term of PM or PM by SNP. Results showed that a 10 μg/m increase in Particulate matter with aerodynamic diameter <2.5 μm (PM) concentrations corresponded to the highest 0.010% (95% CI: 0.002%-0.018%), 0.018% (95% CI: 0.006%-0.029%), 0.019% (95% CI: 0.010%-0.029%) increase in total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), respectively and 0.005% (95% CI: 0.002%-0.008%) decrease in high density lipoprotein cholesterol (HDL-C)-to-LDL-C ratio. As for the PM, similar results were observed. Furthermore, our finding showed an interaction effect of PM and rs505922/rs579459 C allele on TG. Specifically, individuals carrying the rs505922 and rs579459 T allele have higher TG concentrations following PM exposure, with a 10 μg/m increase in PM concentrations corresponding to the highest 0.028% and 0.034% increase in TG, respectively. In conclusion, short-term exposures to ambient particulate matters are associated with a higher blood lipid level, which can be modified by ABO polymorphism. The findings may be useful in identifying vulnerable population according to genetic background.
我们研究了环境颗粒物的主要影响，以及单核苷酸多态性（SNP）是否位于 ABO 基因内会改变这种关系。数据来自于中国北方进行的一项基于家庭的研究。应用广义加性模型和高斯链接，以每个家庭为层，估计环境颗粒物浓度每增加 10μg/m 时血脂水平的百分比变化。通过包括 PM 或 PM 与 SNP 的交叉乘积项进行交互分析。结果表明，环境颗粒物中空气动力学直径<2.5μm（PM）浓度每增加 10μg/m，总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）分别最高增加 0.010%（95%CI：0.002%-0.018%）、0.018%（95%CI：0.006%-0.029%）、0.019%（95%CI：0.010%-0.029%），高密度脂蛋白胆固醇（HDL-C）与 LDL-C 的比值最低降低 0.005%（95%CI：0.002%-0.008%）。对于 PM，也观察到类似的结果。此外，我们的研究结果表明 PM 和 rs505922/rs579459 C 等位基因之间存在相互作用效应。具体来说，携带 rs505922 和 rs579459 T 等位基因的个体在暴露于 PM 后 TG 浓度更高，PM 浓度每增加 10μg/m，TG 浓度最高分别增加 0.028%和 0.034%。总之，短期暴露于环境颗粒物与更高的血脂水平相关，ABO 多态性可以改变这种关系。这些发现可能有助于根据遗传背景识别易感人群。
