Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, Jiangsu Province, People's Republic of China.
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Sci Rep. 2023 Mar 18;13(1):4505. doi: 10.1038/s41598-023-31513-y.
Globally, air pollution is amongst the most significant causes of premature death. Nevertheless, studies on the relationship between fine particulate matter (PM) exposure and blood lipids have typically not been population-based. In a large, community-based sample of residents in Yixing city, we assessed the relationship between short-term outdoor PM exposure and blood lipid concentrations. Participants who attended the physical examination were enrolled from Yixing People's hospital from 2015 to 2020. We collected general characteristics of participants, including gender and age, as well as test results of indicators of blood lipids. Data on daily meteorological factors were collected from the National Meteorological Data Sharing Center ( http://data.cma.cn/ ) and air pollutant concentrations were collected from the China Air Quality Online Monitoring and Analysis Platform ( https://www.aqistudy.cn/ ) during this period. We applied generalized additive models to estimate short-term effects of ambient PM exposure on each measured blood lipid-related indicators and converted these indicators into dichotomous variables (non- hyperlipidemia and hyperlipidemia) to calculate risks of hyperlipidemia associated with PM exposure. A total of 197,957 participants were included in the analysis with mean age 47.90 years (± SD, 14.28). The increase in PM was significantly associated with hyperlipidemia (odds ratio (OR) 1.003, 95% CI 1.001-1.004), and it was still significant in subgroups of males and age < 60 years. For every 10 μg/m increase in PM, triglyceride levels decreased by 0.5447% (95% CI - 0.7873, - 0.3015), the low-density lipoprotein cholesterol concentration increased by 0.0127 mmol/L (95% CI 0.0099, 0.0156), the total cholesterol concentration increased by 0.0095 mmol/L (95% CI 0.0053, 0.0136), and no significant association was observed between PM and the high-density lipoprotein cholesterol concentration. After excluding people with abnormal blood lipid concentrations, the associations remained significant except for the high-density lipoprotein cholesterol concentration. PM was positively correlated with low-density lipoprotein cholesterol and total cholesterol, and negatively correlated with triglyceride, indicating PM can potentially affect health through blood lipid levels.
全球范围内，空气污染是导致早逝的最主要原因之一。然而，针对细颗粒物（PM）暴露与血液脂质之间关系的研究通常并非基于人群。在宜兴市的一个大型社区居民样本中，我们评估了短期户外 PM 暴露与血液脂质浓度之间的关系。2015 年至 2020 年期间，我们从宜兴人民医院参加体检的人员中招募了参与者。我们收集了参与者的一般特征，包括性别和年龄，以及血脂指标的检测结果。我们从国家气象数据共享中心（http://data.cma.cn/）收集了每日气象因素数据，并从中国空气质量在线监测与分析平台（https://www.aqistudy.cn/）收集了空气污染物浓度数据。在此期间，我们应用广义加性模型来估计环境 PM 暴露对每个测量的血液脂质相关指标的短期影响，并将这些指标转换为二分类变量（非高脂血症和高脂血症），以计算与 PM 暴露相关的高脂血症风险。共有 197957 名参与者纳入分析，平均年龄 47.90 岁（±SD，14.28）。PM 浓度的升高与高脂血症显著相关（比值比（OR）1.003，95%置信区间（CI）1.001-1.004），在男性和年龄<60 岁的亚组中仍然显著。PM 每增加 10μg/m，甘油三酯水平降低 0.5447%（95%CI-0.7873，-0.3015），低密度脂蛋白胆固醇浓度升高 0.0127mmol/L（95%CI0.0099，0.0156），总胆固醇浓度升高 0.0095mmol/L（95%CI0.0053，0.0136），PM 与高密度脂蛋白胆固醇浓度之间无显著关联。排除血脂异常者后，除高密度脂蛋白胆固醇浓度外，其他关联仍显著。PM 与低密度脂蛋白胆固醇和总胆固醇呈正相关，与甘油三酯呈负相关，表明 PM 可能通过血液脂质水平对健康产生影响。
