Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, China; Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, The Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Guangdong Medical University, Zhanjiang, China.
Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang, The Marine Medical Research Institute of Guangdong Zhanjiang (GDZJMMRI), Guangdong Medical University, Zhanjiang, China.
Biomed Pharmacother. 2020 May;125:109997. doi: 10.1016/j.biopha.2020.109997. Epub 2020 Feb 13.
RNA therapy is a treatment that regulates cell proteins and cures diseases by affecting the metabolism of mRNAs in cells, which has cut a figure in the studies on various incurable illnesses like hereditary diseases, tumors, etc. In this review, we introduced the discovery and development of RNA therapy and discussed its classification, mechanisms, advantages, and challenges. Moreover, we highlighted how RNA therapy works in killing tumor cells as well as what progresses it has made in related researches. And the development of RNA anti-tumor drugs and the clinical trial process were also included.
RNA 疗法是一种通过影响细胞中 mRNA 的代谢来调节细胞蛋白并治疗疾病的治疗方法，它在遗传性疾病、肿瘤等各种不治之症的研究中崭露头角。在这篇综述中，我们介绍了 RNA 疗法的发现和发展，并讨论了它的分类、机制、优点和挑战。此外，我们还强调了 RNA 疗法如何杀死肿瘤细胞以及它在相关研究中取得的进展。还包括 RNA 抗肿瘤药物的发展和临床试验过程。
