Ha C, Miller L T, Kerkvliet N I
Cell Immunol. 1984 May;85(2):318-29. doi: 10.1016/0008-8749(84)90246-6.
The effect of vitamin B6 on cytotoxic immune responses of T cells, natural killer (NK) cells, cytotoxic antibody production, and macrophage phagocytosis was assessed in 5-week-old female C57B1/6 mice. Mice were fed 20% casein diets with pyridoxine (PN) added at 7, 1, 0.1, or 0 mg/kg diet, which represents 700, 100, 10, and 0% of requirement, respectively. Compared to mice fed 7 or 1 mg PN diet, animals fed 0 or 0.1 mg PN diet showed significantly reduced primary splenic and peritoneal T-cell-mediated cytotoxicity (CMC). Animals fed 0 mg PN diet also showed significantly depressed secondary T CMC of splenic and peritoneal lymphocytes against P815 tumor cells. Complement-dependent antibody-mediated cytotoxicity against P815 cells, phagocytosis of SRBC by macrophages, and native and interferon-induced NK cell activities against YAC cells were not affected by the level of vitamin B6 intake. The percentage of macrophages present in the peritoneal exudate cells was increased in animals fed the 0 mg PN diet. The immune responses were not enhanced or altered by the excess intake of vitamin B6 (7 mg PN). It appears that vitamin B6 is an essential nutrient for maintenance of normal T-cell function in vivo.
在5周龄雌性C57B1/6小鼠中评估了维生素B6对T细胞、自然杀伤（NK）细胞的细胞毒性免疫反应、细胞毒性抗体产生及巨噬细胞吞噬作用的影响。给小鼠喂食添加了7、1、0.1或0 mg/kg吡哆醇（PN）的20%酪蛋白日粮，分别相当于需求量的700%、100%、10%和0%。与喂食7或1 mg PN日粮的小鼠相比，喂食0或0.1 mg PN日粮的动物脾脏和腹膜T细胞介导的细胞毒性（CMC）显著降低。喂食0 mg PN日粮的动物脾脏和腹膜淋巴细胞对P815肿瘤细胞的二次T CMC也显著降低。针对P815细胞的补体依赖性抗体介导的细胞毒性、巨噬细胞对SRBC的吞噬作用以及天然和干扰素诱导的NK细胞对YAC细胞的活性不受维生素B6摄入量的影响。喂食0 mg PN日粮的动物腹膜渗出细胞中巨噬细胞的百分比增加。维生素B6过量摄入（7 mg PN）未增强或改变免疫反应。维生素B6似乎是体内维持正常T细胞功能所必需的营养素。
