Neĭmark M I
Ter Arkh. 1988;60(6):51-4.
A study was made of adrenal function in 2 groups of patients with chronic renal insufficiency on programmed hemodialytic therapy. Insufficiency of gluco- and mineralo-corticoid function of the adrenal glands and hyperfunction of their medulla developed in patients with normal BP and controlled hypertension. In patients with uncontrolled hypertension, insufficiency of adrenal glucocorticoid function was attended by hypercatecholaminemia and aldosteronism. Genesis of the revealed disorders was associated with the loss of hormones into the dialysing solution through the membrane, depletion of adrenocortical functional reserves and disturbance of pulmonary regulation of the level of biologically active substances as a result of microthromboembolization of the vessels of the lesser circulation attending hemodialysis.
对两组接受程序性血液透析治疗的慢性肾功能不全患者的肾上腺功能进行了研究。血压正常和高血压得到控制的患者出现肾上腺糖皮质激素和盐皮质激素功能不全以及肾上腺髓质功能亢进。在高血压未得到控制的患者中，肾上腺糖皮质激素功能不全伴有高儿茶酚胺血症和醛固酮增多症。所发现的这些紊乱的发生机制与激素通过透析膜进入透析液、肾上腺皮质功能储备耗竭以及由于血液透析时肺循环血管微血栓栓塞导致生物活性物质水平的肺调节紊乱有关。
