Tang L, Xiu Y, Yan L, Cui Y, Ma X, Ente M, Zhang Y, Li K, Zhang D
Laboratory of Non-invasive Research Technology for Endangered Species, School of Nature Ecology and Nature Conservation, Beijing Forestry University, Beijing 100083, China.
Xinjiang Uygur Autonomous Region Wild Horse Breeding Research Center, Urumqi, Xinjiang 831704, China.
Helminthologia. 2020 Jan 25;57(1):57-62. doi: 10.2478/helm-2020-0004. eCollection 2020 Mar.
Reintroduction of endangered species to natural habitat is considered as an important tool for conservation. The effect of drug management on captive population of reintroduced species is largely neglected. Decreased drug efficacy could pose a substantial threat to health of animals. More importantly, captive population without proper drug administration could act as transmission medium of resistance nematodes to wild population, making it important to delay the occurrence of drug resistance in captive population. Ivermectin have been used in captive Przewalski's horse () to eradicate intestinal parasitic nematodes annually, while no available studies describing the drug efficacy in the recent ten years. Here, fecal egg counts pre- and post-treatment were performed with ivermectin through individual trace. Both large and small strongyles were identifi ed by larval culture. The fecal egg count reduction was almost 100% based on egg counting data of 448 samples from 13 Przewalski's horses. Feces of two Przewalski's horses were sampled for successive 20 days. Eggs per gram feces usually increased dramatically at the period of 1 - 2 post-treatment days and declined persistently to 0.0 within 15 days. A sustained high ivermectin efficacy against neither nor strongyles was indicated, which can be partly explained by the low deworm frequency.
将濒危物种重新引入自然栖息地被视为保护的一项重要手段。药物管理对重新引入物种的圈养种群的影响在很大程度上被忽视了。药物疗效降低可能对动物健康构成重大威胁。更重要的是，没有适当药物管理的圈养种群可能成为耐药线虫向野生种群传播的媒介，因此延缓圈养种群中耐药性的出现非常重要。伊维菌素已被用于圈养的普氏野马（）中，每年用于根除肠道寄生线虫，但最近十年没有可用的研究描述该药物的疗效。在此，通过个体追踪对伊维菌素治疗前后的粪便虫卵计数进行了检测。通过幼虫培养鉴定了大型和小型圆线虫。根据来自13匹普氏野马的448个样本的虫卵计数数据，粪便虫卵计数减少率几乎为100%。对两匹普氏野马的粪便连续20天进行采样。每克粪便中的虫卵通常在治疗后1 - 2天内急剧增加，并在15天内持续下降至0.0。结果表明，伊维菌素对大型和小型圆线虫均未表现出持续的高效，这可以部分归因于驱虫频率较低。
