英夫利昔单抗诱导的扁平苔藓样毛发角化病：一例报告。

McPhie Meghan L, Wang Ami, Molin Sonja, Herzinger Thomas

School of Medicine, Queen's University, Kingston, ON, Canada.

Department of Pathology and Molecular Medicine, Queen's University, Kingston, ON, Canada.

SAGE Open Med Case Rep. 2020 Jan 28;8:2050313X20901967. doi: 10.1177/2050313X20901967. eCollection 2020.

Infliximab is a tumor necrosis factor-alpha inhibitor used to treat a range of inflammatory diseases. Most reports of cutaneous eruptions from tumor necrosis factor-alpha inhibitors have described the paradoxical development of psoriasis or psoriasiform drug reaction. In our report, we present a 31-year-old female with inflammatory bowel disease who developed an unusual lichenoid drug reaction to infliximab involving the hair follicles, resulting in progressive global alopecia. Clinical features and histopathological findings were consistent with drug-induced lichen planopilaris with eosinophils and lichenoid dermatitis.

英夫利昔单抗是一种用于治疗多种炎症性疾病的肿瘤坏死因子-α抑制剂。大多数关于肿瘤坏死因子-α抑制剂引起皮肤疹的报告都描述了银屑病或银屑病样药物反应的反常发展。在我们的报告中，我们介绍了一名31岁患有炎症性肠病的女性，她对英夫利昔单抗产生了一种不寻常的累及毛囊的苔藓样药物反应，导致进行性全秃。临床特征和组织病理学发现与药物性嗜酸性粒细胞性扁平苔藓样毛发扁平苔藓和苔藓样皮炎一致。