Th17细胞在复发缓解型多发性硬化症（RRMS）以及继发进展型多发性硬化症（SPMS）中均有所增加，而Th17的其他多种表型仅在RRMS中增加。
Th17 cells increase in RRMS as well as in SPMS, whereas various other phenotypes of Th17 increase in RRMS only.
作者信息
Kalra S, Lowndes C, Durant L, Strange R C, Al-Araji A, Hawkins Clive P, Curnow S John
机构信息
Royal Stoke MS Centre of Excellence, Neurology Department, University Hospital North Midlands NHS Trust, UK.
Centre for Translational Inflammation Research, Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, UK.
出版信息
Mult Scler J Exp Transl Clin. 2020 Jan 28;6(1):2055217319899695. doi: 10.1177/2055217319899695. eCollection 2020 Jan-Mar.
BACKGROUND
The nature and extent of inflammation seen in multiple sclerosis (MS) varies throughout the course of the disease. Changes seen in CD4+ T-helper cells in relapsing-remitting (RR) MS and secondary progressive (SP) MS might differ qualitatively and/or quantitatively.
OBJECTIVE
The objective of this paper is to study the frequencies of all major CD4+ T-helper subtypes - Th17, Th22 and Th1 lineage cells - in relapse, remission and secondary progression alongside CCR6 status, a chemokine receptor involved in migration of these cells into the central nervous system.
METHODS
We compared 100 patients (50 RRMS and 50 SPMS) and 50 healthy volunteers and performed flow cytometric analysis of lymphocytes in blood samples.
RESULTS
We demonstrated raised frequencies of various cell types along the Th17 axis; Th17, Th17.1 (IL-17+ interferon gamma+) and dual IL-17+ IL-22+ cells in RRMS. Th22 and CCR6+ Th1 cells (nonclassical Th1) were also increased in RRMS. All these cells were CCR6+. Only Th17 frequencies were elevated in SPMS.
CONCLUSIONS
Increased frequencies of Th17 cells are implicated both in RRMS and SPMS. The CCR6 pathway includes Th17, Th22 and Th1 nonclassical cells, of which Th22 and Th1 cells represent the greatest subsets in MS.
背景
多发性硬化症（MS）中炎症的性质和程度在疾病过程中各不相同。复发缓解型（RR）MS和继发进展型（SP）MS中CD4 +辅助性T细胞的变化可能在质量和/或数量上有所不同。
目的
本文的目的是研究复发期、缓解期和继发进展期所有主要CD4 +辅助性T细胞亚型（Th17、Th22和Th1谱系细胞）的频率以及CCR6状态，CCR6是一种参与这些细胞迁移到中枢神经系统的趋化因子受体。
方法
我们比较了100例患者（50例RRMS和50例SPMS）和50名健康志愿者，并对血样中的淋巴细胞进行了流式细胞术分析。
结果
我们证明了RRMS中沿Th17轴的各种细胞类型的频率升高；Th17、Th17.1（IL-17 +干扰素γ+）和双IL-17 + IL-22 +细胞。RRMS中Th22和CCR6 + Th1细胞（非经典Th1）也增加。所有这些细胞均为CCR6 +。SPMS中仅Th17频率升高。
结论
RRMS和SPMS中均涉及Th17细胞频率增加。CCR6途径包括Th17、Th22和非经典Th1细胞，其中Th22和Th1细胞是MS中最大的亚群。
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