Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Immun Inflamm Dis. 2024 Mar;12(3):e1213. doi: 10.1002/iid3.1213.
Berberine is a benzylisoquinoline alkaloid found in such plants as Berberis vulgaris, Berberis aristata, and others, revealing a variety of pharmacological properties as a result of interacting with different cellular and molecular targets. Recent studies have shown the immunomodulatory effects of Berberine which result from its impacts on immune cells and immune response mediators such as diverse T lymphocyte subsets, dendritic cells (DCs), and different inflammatory cytokines. Multiple sclerosis (MS) is a chronic disabling and neurodegenerative disease of the central nervous system (CNS) characterized by the recruitment of autoreactive T cells into the CNS causing demyelination, axonal damage, and oligodendrocyte loss. There have been considerable changes discovered in MS regards to the function and frequency of T cell subsets such as Th1 cells, Th17 cells, Th2 cells, Treg cells, and DCs. In the current research, we reviewed the outcomes of in vitro, experimental, and clinical investigations concerning the modulatory effects that Berberine provides on the function and numbers of T cell subsets and DCs, as well as important cytokines that are involved in MS.
小檗碱是一种苯并异喹啉生物碱，存在于小檗属植物如小檗、小檗等植物中，由于与不同的细胞和分子靶点相互作用，显示出多种药理学特性。最近的研究表明，小檗碱具有免疫调节作用，这是由于它对免疫细胞和免疫反应介质的影响，如不同的 T 淋巴细胞亚群、树突状细胞 (DC) 和不同的炎症细胞因子。多发性硬化症 (MS) 是一种中枢神经系统 (CNS) 的慢性致残性和神经退行性疾病，其特征是自身反应性 T 细胞募集到 CNS 中，导致脱髓鞘、轴突损伤和少突胶质细胞丢失。在 MS 中，T 细胞亚群（如 Th1 细胞、Th17 细胞、Th2 细胞、Treg 细胞和 DC）的功能和频率发生了相当大的变化。在目前的研究中，我们综述了关于小檗碱对 T 细胞亚群和 DC 功能和数量以及参与 MS 的重要细胞因子的调节作用的体外、实验和临床研究结果。
