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以急性肝炎为表现的宫颈转移性黏液腺癌

Metastatic Mucinous Adenocarcinoma of the Cervix Presenting as Acute Hepatitis.

作者信息

Kundumadam Shanker, Laharwani Hansini, Azhikkalayil Shafeek, Das Gokul

机构信息

Internal Medicine, Wayne State University School of Medicine, Detroit, USA.

Pathology, University of Mississippi Medical Center (UMMC), Jackson, USA.

出版信息

Cureus. 2020 Jan 10;12(1):e6620. doi: 10.7759/cureus.6620.

DOI:10.7759/cureus.6620
PMID:32064200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7008751/
Abstract

Cervical cancer is well known to cause metastasis in liver. Not usually they present in a pattern of acute hepatitis with the liver enzymes trending above the range of thousands. Here we present an interesting case of a patient who presented as acute hepatitis in the setting of metastatic cervical cancer to the liver. She presented with elevated liver enzymes above thousands. Her imaging studies revealed new metastatic lesions in the liver. She was subsequently started on chemotherapy but unfortunately, two months later developed septic shock and expired. To our knowledge this is the only case describing a malignancy with metastasis to the liver presenting as an acute hepatitis picture. All the other cases that have been described in the literature presented with acute liver failure.

摘要

众所周知,宫颈癌会导致肝转移。通常情况下,它们不会表现为急性肝炎的模式,肝酶水平也不会升至数千以上。在此,我们报告一例有趣的病例,一名患者因宫颈癌肝转移而表现为急性肝炎。她的肝酶水平升至数千以上。影像学检查显示肝脏出现新的转移病灶。随后她开始接受化疗,但不幸的是,两个月后出现感染性休克并死亡。据我们所知,这是唯一一例描述恶性肿瘤肝转移表现为急性肝炎的病例。文献中描述的所有其他病例均表现为急性肝衰竭。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/aefdb18bdac8/cureus-0012-00000006620-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/6fd13e2ac873/cureus-0012-00000006620-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/71a9a630bb79/cureus-0012-00000006620-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/aefdb18bdac8/cureus-0012-00000006620-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/6fd13e2ac873/cureus-0012-00000006620-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/71a9a630bb79/cureus-0012-00000006620-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52dd/7008751/aefdb18bdac8/cureus-0012-00000006620-i03.jpg

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本文引用的文献

1
Elevated Liver Enzymes in Asymptomatic Patients - What Should I Do?无症状患者的肝酶升高——我该怎么做?
J Clin Transl Hepatol. 2017 Dec 28;5(4):394-403. doi: 10.14218/JCTH.2017.00027. Epub 2017 Sep 21.
2
Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology.日本妇产科学会妇科肿瘤学委员会年度报告
J Obstet Gynaecol Res. 2015 Feb;41(2):167-77. doi: 10.1111/jog.12596. Epub 2014 Nov 5.
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Metastatic prostatic carcinoma presenting as fulminant hepatic failure.以暴发性肝衰竭为表现的转移性前列腺癌。
South Med J. 2008 Oct;101(10):1049-50. doi: 10.1097/SMJ.0b013e31817c74c3.
4
Fulminant hepatic failure resulting from small-cell lung cancer and dramatic response of chemotherapy.小细胞肺癌导致的暴发性肝衰竭及化疗的显著反应。
World J Gastroenterol. 2006 Apr 21;12(15):2466-8. doi: 10.3748/wjg.v12.i15.2466.
5
Acute liver failure secondary to hepatic infiltration: a single centre experience of 18 cases.继发于肝脏浸润的急性肝衰竭:单中心18例经验
Gut. 1998 Apr;42(4):576-80. doi: 10.1136/gut.42.4.576.