Kamal Mohamed M, Kassem Dina H
Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
The Center for Drug Research and Development, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.
Front Cell Dev Biol. 2020 Jan 29;8:16. doi: 10.3389/fcell.2020.00016. eCollection 2020.
Diabetes mellitus (DM) is an alarming metabolic disease in which insulin secreting β-cells are damaged to various extent. Unfortunately, although currently available treatments help to manage the disease, however, patients usually develop complications, as well as decreased life quality and increased mortality. Thus, efficient therapeutic interventions to treat diabetes are urgently warranted. During the past years, mesenchymal stem cells (MSCs) have made their mark as a potential weapon in various regenerative medicine applications. The main fascination about MSCs lies in their potential to exert reparative effects on an amazingly wide spectrum of tissue injury. This is further reinforced by their ease of isolation and large expansion capacity, as well as demonstrated multipotency and immunomodulatory activities. Among all the sources of MSCs, those isolated from umbilical cord-Wharton's jelly (WJ-MSCs), have been proved to provide a great source of MSCs. WJ-MSCs do not impose any ethical concerns as those which exist regarding ESCs, and represent a readily available non-invasive source, and hence suggested to become the new gold standard for MSC-based therapies. In the current review, we shall overview achievements, as well as challenges/hurdles which are standing in the way to utilize WJ-MSCs as a novel efficient therapeutic modality for DM.
糖尿病（DM）是一种令人担忧的代谢性疾病，其中分泌胰岛素的β细胞会受到不同程度的损伤。不幸的是，尽管目前可用的治疗方法有助于控制该疾病，但患者通常会出现并发症，生活质量下降，死亡率增加。因此，迫切需要有效的治疗干预措施来治疗糖尿病。在过去几年中，间充质干细胞（MSCs）已成为各种再生医学应用中的一种潜在武器。对MSCs的主要吸引力在于它们有可能对广泛的组织损伤发挥修复作用。它们易于分离、具有强大的扩增能力，以及已证实的多能性和免疫调节活性，进一步增强了这种吸引力。在所有MSCs来源中，从脐带华通氏胶分离的MSCs（WJ-MSCs）已被证明是MSCs的一个重要来源。WJ-MSCs不存在与胚胎干细胞相关的任何伦理问题，是一种随时可用的非侵入性来源，因此有望成为基于MSCs治疗的新金标准。在本综述中，我们将概述利用WJ-MSCs作为糖尿病新型有效治疗方式的成果以及面临的挑战。
