一项使用整体分析技术的真性红细胞增多症FDG-PET/CT试点研究。
A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques.
作者信息
Ayubcha Cyrus, Hosoya Hitomi, Mehdizadeh Seraj Siavash, Zirakchian Zadeh Mahdi, M S E Thomas Werner, Alavi Abass
机构信息
Department of Radiology, Perelman School of Medicine, University of Pennsylvania, PA, United States.
Department of Medicine, Pennsylvania Hospital, University of Pennsylvania, Philadelphia, PA, United States.
出版信息
Asia Ocean J Nucl Med Biol. 2020 Winter;8(1):64-68. doi: 10.22038/aojnmb.2019.41192.1278.
OBJECTIVES
Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV).
METHODS
This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology.
RESULTS
All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients.
CONCLUSION
Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV.
目的
功能成像提供了一种非侵入性方法，可捕捉骨髓增殖性肿瘤（如真性红细胞增多症，PV）中红骨髓的高代谢特性。
方法
本研究采用定量整体分析方法，分析了6例诊断为PV的患者和6例年龄及性别匹配的对照者的FDG-PET/CT扫描结果（n = 12）。
结果
与匹配的对照者相比，所有PV患者各骨骼结构骨髓中的活性均升高，平均标准化摄取值方面（股骨颈p = 0.01，腰椎p = 0.02，骨盆p = 0.002，胸骨p = 0.04）。在接受治疗和未接受治疗的PV患者中观察到脾脏摄取存在显著差异。
结论
我们的研究例证了PET在反映与PV相关的活跃骨髓活动方面的潜在效用。未来的研究可能会进一步证实并详细阐述PET衍生的代谢数据在PV中的应用。
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