Department of Surgery, University of Toledo Medical Center, Toledo, OH, USA.
Inova Fairfax Hospital, Falls Church, VA, USA.
Clin Transplant. 2020 Apr;34(4):e13826. doi: 10.1111/ctr.13826. Epub 2020 Mar 6.
Procurement practices across organ procurement organizations (OPOs) for donation after cardiac death (DCD) transplants have not been evaluated.
A national telephone survey of all 58 OPOs inquiring about their procurement practices of DCD organs was conducted. Policies concerning maximum donor body mass index (BMI), location of care withdrawal, pre-mortem heparin administration, vasodilator use, wait times after declaration of death before incisions, inclinations between rapid laparotomy and pre-mortem cannulation, and maximum time before aborting DCD procurement were queried.
The survey revealed substantial differences across OPOs. Donor BMI restriction was considered by 36 of 58 OPOs, and 23 sites preferred OR for donor withdrawal of care. Pre-mortem heparin was utilized by 53 OPOs. Only 2 recommended vasodilators. Minimum wait time of 5-minutes was implemented by 41 OPOs. Rapid laparotomy was preferred by 57 organizations. 28 OPOs had a 90-minute limit before aborting DCD procurement.
There are substantial variations across OPO protocols for procuring DCD organs. Current practices do not conform to ASTS guidelines for DCD procurement. Further investigations are needed to quantify the impact of OPO policies on transplant outcomes.
心脏死亡后器官捐献(DCD)移植的器官采购实践在各个器官获取组织(OPO)中尚未得到评估。
对全国所有 58 个 OPO 进行了一次全国性的电话调查,询问他们对 DCD 器官的采购做法。调查内容包括:有关供体体重指数(BMI)最大值、停止治疗地点、生前肝素给药、血管扩张剂使用、宣布死亡后进行切口前的等待时间、快速剖腹术和生前插管之间的倾斜度,以及中止 DCD 采购的最长时间等政策。
调查显示,OPO 之间存在很大差异。有 36 个 OPO 考虑了供体 BMI 限制,有 23 个地点倾向于在 OR 进行供体停止治疗。53 个 OPO 使用了生前肝素。只有 2 个 OPO 推荐使用血管扩张剂。41 个 OPO 实施了 5 分钟的最短等待时间。57 个组织更喜欢快速剖腹术。28 个 OPO 在中止 DCD 采购前有 90 分钟的限制。
OPO 采集 DCD 器官的协议存在很大差异。目前的做法不符合 ASTS 关于 DCD 采购的指南。需要进一步调查以量化 OPO 政策对移植结果的影响。