Advanced Porous Materials Unit (APMU), IMDEA Energy Institute, Av. Ramón de la Sagra 3, 28935 Móstoles-Madrid, Spain.
Nano-Oncology Unit, Health Research Institute of Santiago de Compostela (IDIS), Clinical University Hospital of Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain.
Nanoscale. 2020 Feb 27;12(8):4839-4845. doi: 10.1039/c9nr08127e.
Despite the great interest in RNA therapeutics, the development of a successful gene delivery process is still a major challenge. We propose an efficient nucleic acid entrapment into the mesopores of biocompatible nanoscaled metal-organic frameworks. Their rapid cellular uptake together with RNA protection and release led to a relevant in vitro gene activity.
尽管人们对 RNA 治疗学有着浓厚的兴趣，但开发成功的基因传递过程仍然是一个主要挑战。我们提出了一种有效的将核酸包埋在生物相容性纳米尺度金属有机骨架的介孔中的方法。它们的快速细胞摄取以及 RNA 的保护和释放导致了相关的体外基因活性。
