Department of Drugs and Medicines, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil.
Department of Drugs and Medicines, São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP, Brazil; Department of Biological and Health Sciences, Universidade de Araraquara - UNIARA, Araraquara, SP, Brazil.
Eur J Pharm Biopharm. 2018 Jun;127:112-119. doi: 10.1016/j.ejpb.2018.02.009. Epub 2018 Feb 8.
Drug delivery systems have been used to reduce adverse effects and improve the efficacy of therapies. Drug carriers have been developed over the years, but they have limitations. γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOF) have significant advantages due to their biocompatibility and environmental safety, besides crystallinity and porosity. Herein, γ-CD-MOFs were synthesised with different metals as nodes and investigated. Uniform mesoporous γ-CD-MOFs were obtained and showed an absence of toxicity in HepG2 and Caco-2 cells. The longer controlled release was verified for γ-CD-MOFs, with a maximum of 62% released in 12 h. An inflammation experiment was performed in mice and activity equivalent to the positive control was verified. γ-KCD-MOFs and γ-NaCD-MOFs reached activity after 6 h of administration, however this happened after 24 h in γ-FeCD-MOFs, being more effective than the positive control. Considering the ability for drug entrapment, easy preparation and controlled release, this class of material allows potential applications in drug delivery systems.
药物传递系统已被用于减少不良反应并提高治疗效果。多年来已经开发出药物载体，但它们存在局限性。基于γ-环糊精的金属有机骨架（γ-CD-MOF）具有生物相容性和环境安全性，除了结晶性和多孔性外，还有显著的优势。本文合成了具有不同金属作为节点的γ-CD-MOF 并进行了研究。得到了均匀的介孔 γ-CD-MOF，并且在 HepG2 和 Caco-2 细胞中没有表现出毒性。验证了 γ-CD-MOF 的更长时间的控制释放，在 12 小时内最多释放 62%。在小鼠中进行了炎症实验，验证了与阳性对照相当的活性。γ-KCD-MOF 和 γ-NaCD-MOF 在给药 6 小时后达到活性，而 γ-FeCD-MOF 在 24 小时后达到活性，比阳性对照更有效。考虑到药物包埋能力、易于制备和控制释放，此类材料允许在药物传递系统中潜在应用。
